Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment
Vasiliy Yegorovich Novikov , Sergey Alekseyevich Ilyukhin , Yelena Vasilyevna Pozhilova
Reviews on Clinical Pharmacology and Drug Therapy ›› 2012, Vol. 10 ›› Issue (4) : 63 -66.
Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment
The dynamics of the acute inflammatory response was observed in the experiment modeling caragenin-induced rat paw inflammation. The changes in the volume of damaged limb (paw edema) and indices of free radical oxidation were registered. Acetylsalicylic acid in the dose of 100 mg/kg was shown to reduce the development of inflammation. Hypoxen and metaprot in the dose of 50 mg/kg have got low anti-inflammatory activity, but potentiated the effect of acetylsalicylic acid. Simultaneous enteral administration of hypoxen and metaprot with the acetylsalicylic acid during the treatment with caragenin the powerful anti-inflammatory effect was marked, it was presented with a significant decrease in the parameters of inflammation recorded and rapid recovery of the damaged limb. The combination of hypoxen with acetylsalicylic acid was the most effective one.
hypoxen / metaprot / acetylsalicylic acid / caragenin / acute inflammation
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Novikov V.Y., Ilyukhin S.A., Pozhilova Y.V.
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