Antihistamine activity of the new peptidepreparation from the cod liver
Kirill Leonidovich Kryshen , Dmitriy Valentinovich Demchenko , Olga Nikolayevna Pozharitskaya , Marina Nikolayevna Makarova , Yaroslav Aleksandrovich Gushchin , Anna Vladimirovna Rybakova , Anastasiya Vladimirovna Rydlovskaya , Aleksandr Nikolayevich Shikov , Valeriy Gennadyevich Makarov
Reviews on Clinical Pharmacology and Drug Therapy ›› 2012, Vol. 10 ›› Issue (4) : 49 -53.
Antihistamine activity of the new peptidepreparation from the cod liver
The effect of the peptide substance on the induced production of histamine by culture of basophile, interaction of the preparation with the H1-histamine receptors and possible sedative effect on animal models were studied. The introduction of the peptide substance in cell culture of basophile didn’t have a significant effect on the histamine release. Study of the interaction of the polypeptide substance with H1-histamine receptors of guinea pig ileum showed that the preparation inhibits the response of unstriated muscles to histamine. The effect was similar to antihistamine drug - ketotifen. In the models of “open field” and “elevated criss-cross labyrinth” it was found that the peptide preparation hasn’t a sedative effect.
peptide preparation / histamine / basophiles / cell culture / sedative activity
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Kryshen K.L., Demchenko D.V., Pozharitskaya O.N., Makarova M.N., Gushchin Y.A., Rybakova A.V., Rydlovskaya A.V., Shikov A.N., Makarov V.G.
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