Antihistamine activity of the new peptidepreparation from the cod liver
Kirill Leonidovich Kryshen , Dmitriy Valentinovich Demchenko , Olga Nikolayevna Pozharitskaya , Marina Nikolayevna Makarova , Yaroslav Aleksandrovich Gushchin , Anna Vladimirovna Rybakova , Anastasiya Vladimirovna Rydlovskaya , Aleksandr Nikolayevich Shikov , Valeriy Gennadyevich Makarov
Reviews on Clinical Pharmacology and Drug Therapy ›› 2012, Vol. 10 ›› Issue (4) : 49 -53.
The effect of the peptide substance on the induced production of histamine by culture of basophile, interaction of the preparation with the H1-histamine receptors and possible sedative effect on animal models were studied. The introduction of the peptide substance in cell culture of basophile didn’t have a significant effect on the histamine release. Study of the interaction of the polypeptide substance with H1-histamine receptors of guinea pig ileum showed that the preparation inhibits the response of unstriated muscles to histamine. The effect was similar to antihistamine drug - ketotifen. In the models of “open field” and “elevated criss-cross labyrinth” it was found that the peptide preparation hasn’t a sedative effect.
peptide preparation / histamine / basophiles / cell culture / sedative activity
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Kryshen K.L., Demchenko D.V., Pozharitskaya O.N., Makarova M.N., Gushchin Y.A., Rybakova A.V., Rydlovskaya A.V., Shikov A.N., Makarov V.G.
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