METHODOLOGy OF MEMORy STUDy IN PHARMACOLOGICAL CORRECTION OF ITS DISORDERS IN ALCOHOLICS SUFFERED FROM TRAUMATIC bRAIN INjURy

Abstract

The main goal of the current research was to assess memory impairments via learning curves and its restoration during the process of rehabilitative treatment of alcoholic patients having traumatic brain injury with pharmacological correction. We applied a mathematical model Y = B3*exp(-B2*(X-1))+B4*(1-exp(-B2*(X-1))), where X is the trial number; Y is the number of recalled correct words, B2 is the learning rate, B3 is readiness to learn and B4 is ability to learn. Readiness to learn and ability to learn were significantly below in alcoholic patients in comparison with healthy participants. Treatment with vasorelaxants Cinnarizine and Dibazol, central muscle relaxant Baclofen, nootropics Nootropil and Aethimizol, as well as actoprotector Metaprot (Bemithyl) returned readiness to learn up (shortterm memory) to normal values. However, ability to learn (long-term memory) was restored only with Dibazol. Use of 10 words in a list of Luria's memory test is insufficient for exact assessment of the long-term memory and should be increased up to 16 words.

Keywords

memory / learning curve / mathematical model / nootropics / alcoholics / traumatic brain injury

References

[1] Ерышев О. Ф., Рыбакова Т. Г., Шабанов П. Д. Алкогольная зависимость. — СПб.: ЭЛБИ-СПб, 2002.

[2] Лурия А. Р. Высшие корковые функции человека и их нарушения при локальных повреждениях мозга. — Москва: Изд-во МГУ, 1962.

[3] Сапронов Н. С., Шабанов П. Д., Степанов И. И., Ефремов О. М., Лосев Н. А. Восстановительное лечение нарушения памяти у больных наркоманией и алкоголизмом с использованием акупунктуры // Мед. акад. журн. — 2010. — Т. 10. № 4. — С. 229– 234.

[4] Степанов И. И., Ефремов О. М., Суворов Н. Б., Даниловский М. М., Майданов Н. П., Шклярук С. П. Информативность математической модели процесса обучения // Информационно-управляющие системы. — 2011. № 1. — С. 34–40.

[5] Частотный словарь русского языка. — М.: Русский язык, 1977.

[6] Шабанов П. Д. Руководство по наркологии.— СПб.: Лань, 1998.

[7] Шабанов П. Д. Биология алкоголизма. — СПб.: Лань, 1998.

[8] Шабанов П. Д., Штакельберг О. Ю. Наркомании: патопсихология, клиника, реабилитация. — СПб.: Лань, 2000.

[9] Ashla P. M., McMurtray A. M., Licht E., Mendez M. F. Retrospective posttraumatic amnesia in traumatic brain injury // J. Neuropsychiatry Clin. Neurosci. — 2009. — Vol. 21, № 4. — P. 467–468.

[10] Geary E. K., Kraus M. F., Pliskin N. H., Little D. M. Verbal learning differences in chronic mild traumatic brain injury // J. Int. Neuropsychol. Soc. — 2010 — Vol. 16, № 3. — P. 506–516.

[11] D'Argembeau A., Van Der Linden M., Verbanck P., Noel X. Autobiographical memory in non-amnesic alcohol-dependent patients // Psychol. Med. — 2006 — Vol. 36, № 3. — P. 1707–1715.

[12] Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. California Verbal Learning Test — Second Edition: Adult version manual. San Antonio, TX: The Psychological Corporation, 2000.

[13] Draper N. R., Smith H. Applied regression analysis. New York: John Wiley and Sons, Inc., 1981.

[14] Ersche K. D., Clark L., London M., Robbins T. W., Sahakian B. J. Profile of executive and memory function associated with amphetamine and opiate dependence // Neuropsychopharmacology. — 2006. Vol. 31, № 4. — P. 1036–1047.

[15] Grodins F. S. Control theory and biological systems. New York and London: Columbia University Press, 1963.

[16] Himmelblau D. M. Process analysis by statistical methods. New York: John Wiley and Sons, Inc., 1970.

[17] Milsum J. H. Biological control systems analysis. New York and London: McGraw-Hill Book Company, 1966.

[18] Miller G. A. The magical number seven, plus or minus two: Some limits on our capacity for processing information // Psychol. Rev. — 1956. Vol. 63, № 1. — P. 81–97.

[19] Pitel A. L., Witkowski, T., Vabret, F., Guillery-Girard, B., Desgranges, B., Eustache, F., Beaunieux, H. Effect of episodicandworkingmemoryimpairmentsonsemantic and cognitive procedural learning at alcohol treatment entry // Alcohol. Clin. Exp. Res. — 2007. Vol. 31, № 2. — P. 238–248.

[20] Serino A., Ciaramelli E., Di Santantonio A., Ladavas E. A rehabilitative program for central executive deficits after traumatic brain injury // Brain Cogn. — 2006. Vol. 60, № 2. — P. 213–214.

[21] Skandsen T., Finnanger T. G., Andersson S., Lydersen S., Brunner J. F., Vik A. Cognitive impairment 3 months after moderate and severe traumatic brain injury: a prospective follow-up study // Arch. Phys. Med. Rehabil. — 2010. Vol. 91, № 12. — P. 1904–1913.

[22] Verdejo-Garcia A., Bechara A., Recknor E. C., Perez-Garcia M. Executive dysfunction in substance dependent individuals during drug use and abstinence: an examination of the behavioral, cognitive and emotional correlates of addiction // J. Int. Neuropsychol. Soc. — 2006. Vol. 12, № 3. — P. 405–415.

RIGHTS & PERMISSIONS

Stepanov I.I., Gavrilova I.V., Losev N.A., Sapronov N.S., Shabanov P.D.