Psychological status of elderly patients suffering arterial hypertension in metabolic syndrome against the background of chronotherapy

Abstract

Arterial hypertension in the metabolic syndrome in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. It is shown that the severity of these deviations of the psychological continuum significantly decreases after 1 year, under the influence of an antihypertensive fixed combination of amlodipine, mesinopril and rosuvastatin in the chronotherapy mode (evening reception), than in the traditional application (morning reception in the equivalent dosage of 5/10/10 mg per day in both cases. The dynamics of cognitive impairment in chronotherapeutical approach in patients 60–74 flights from arterial hypertension with metabolic syndrome is characterized by a significant increase in the average score on a scale MMSE, f source 17.8 ± 0.3 to 23.5 ± 0.4 points (р < 0.001), against 16.9 ± 0.3 to 20.4 ± 0.4 points (р < 0.001) in the morning taking the drug. Situational anxiety decreased from 40.8 ± 2.2 to 30.6 ± 1.8 points (р > 0.05) and from 40.0 ± 2.5 to 32.1 ± 2.0 points (р > 0.05), personal anxiety from 48.8 ± 2.0 to 25.4 ± 1.9 (р < 0.001) and from 44.9 ± 1.9 to 30.7 ± 1.7 (р < 0.01) points in the evening and morning the reception, respectively. Depressive disorders decreased slightly more significantly in chronotherapy (14.1% vs. 7.7%) than in the traditional scheme, but despite this, both cases with (groups) corresponded to depressive spectrum disorders. The results obtained indicate that chronotherapy is more effective than the traditional use of a fixed combination of amlodipine, lisinopril and rosuvastatin in arterial hypertension with metabolic syndrome.

Keywords

psychological continuum / arterial hypertension / metabolic syndrome / fixed combination of amlodipine, mesinopril and rosuvastatin / old age / chronotherapy

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Agarkov N.M., Okhotnikov O.I., Korneeva S.I., Moskaleva E.O., Moskalev A.A., Kolomyets V.I., Markelova A.M.