The influence of polymorphism on CCR5DELTA32 on the clinical course of acute respiratory viral infection

Abstract

In the Armed Forces of the Russian Federation, the spread of influenza and acute respiratory viral diseases is associated with the characteristics of military service (adaptation of recruits, barracks placement, military professional and environmental impacts) and is the most important problem of military medicine. Flu and acute respiratory viral infections are characterized by intensity of the epidemic process with a wide geographical spread and high frequency of complications and lethal outcomes. It is established that the individual response of an immune system to infectious agents exposure is characterized by high variability. The variability of the individual response to the effect of etiologic agents of acute respiratory viral diseases increases the importance of searching for molecular factors that determine pathogenesis variants of this infectious pathology and can be applied for risk group formation of severe and complicated clinical course development, and for planning an individual therapy approach. Molecular genetic analysis of the polymorphism of key genes determining the efficiency of an immune response allows to predict predilection, severity of the clinical course and complications of infectious diseases. This article examines the relationship between carriage of the CCR5DELTA32 allele and increased incidence, severity and risk of complications of influenza and acute respiratory viral infections.

Keywords

chemokine receptors / virus infection / polymorphism / acute respiratory viral infections / pneumonia / CD4+ cells / protein receptors / grippe / mutation

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