An integrated approach to the prevention of sudden cardiac death, developed in the laboratory of biotechnical systems and technologies in military innovative technopolis «Era»

Abstract

A comprehensive approach to the prevention of sudden cardiac death, developed in the laboratory of «Biotechnical systems and technologies» of the Military innovative technopolis «Era», is considered in order to further reduce the level of mortality from diseases of the circulatory system among servicemen of the Ministry of defense of the Russian Federation. The paper presents strategies to reduce sudden cardiac death and the main directions of its primary prevention in the military of the Ministry of defense of the Russian Federation – questionnaires, ambulatory electrocardiography and genetic typing. It was found that in the case of identifying risk factors for sudden cardiac death according to the questionnaire or deviation of electrocardiogram, it is advisable to classify such soldiers as a moderate risk of its development and perform the second stage of the survey – long-term ambulatory electrocardiography using individual wearable devices, but most of them are not without drawbacks. The activity of research laboratories of the Military innovative Technopolis «Era», in particular laboratory of monitoring of vital functions of an organism of the military personnel and prevention of pathological condition on approbation of the individual wearable devices allowing to register the electrocardiogram for the purpose of their completion and introduction in daily activity, and also laboratory of molecular genetic researches on identification of the main genetic anomalies responsible for possibility of emergence of sudden cardiac death is analyzed. It is revealed that the work of laboratories is based on the development of all three areas of prevention of sudden cardiac death. A pilot project was launched to assess the effectiveness of the questionnaire and perform standard electrocardiography with further transfer of information to a center for its processing. Testing of existing individual wearable devices for outpatient electrocardiography and the study of the genetic basis of sudden cardiac death is carried out. Further work of the laboratories will lead to the development and implementation of a simple and understandable algorithm for stratifying the risk of sudden cardiac death, starting with an affordable and cost-effective questionnaire and ending with a fairly complex and expensive genetic typing.

Keywords

sudden cardiac death / prevention / military innovative technopolis «Era» / individual wearable devices / vital body functions / ambulatory electrocardiography / stratification of the risk of sudden death

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