Dynamic of the functional state indices of patients with chronic hepatitis C during the therapy with antiviral drugs depending on the age of patients

Abstract

We conducted a comparative analysis of the dynamic parameters of physiological systems voltage of the patient’s organism with chronic hepatitis C from all groups of viruses receiving antiviral therapy by means of polyfunctional psychophysiological testing (stress testing). It was revealed that there is an increase in the stress index in the first six months of therapy; an increase in the index of low-frequency waves of cardiac rhythm with a simultaneous decrease in power of contribution of high-frequency waves, as well as an increase in a coefficient of the vagosympathetic balance in the first three months of taking medications; decrease in values of skin-galvanic reaction in the first three months of therapy. These changes indicate an increase in the activity of sympathetic part of an autonomous nervous system, the predominance of a central contour of regulation in patients of different age groups against the background of treatment with antiviral drugs. In addition, there was a pronounced tendency to increase in values ofthe neurotic index in different age groups during the first six months of antiviral therapy and to stabilize it by the end of the observation period. The indicator of mental tension increased in both age groups during the whole period of observation, however, its values did not exceed the level corresponding to the state of psychological adaptation to workloads. The results of the study testify to the tension o compensatory-adaptive mechanisms of organism of patients with chronic viral hepatitis C against the background of antiviral drugs in different age groups. These changes are more pronounced in the age group from 40 to 58.

Keywords

functional status / chronic viral hepatitis C / an antiviral therapy / psychophysiological indices / stress reaction / skin-galvanic reaction / compensatory-adaptive mechanisms / neurotic index / depression

References

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