Adaptation at combined (cold and painful) influence in experiment

Abstract

In experiment on rats males of the line Vistar regularities of adaptation are considered at combined (cold – swimming in water at a temperature +7oС with the lead sinker (10% of body weight) attached to a root of a tail and painful – introduction under a plantar aponeurosis of 2% of solution of formalin) influence. It is established that cold influence reduces adaptive abilities of an organism and quicker leads to disadaptation. Painful influence stimulates ability to adaptation, but negatively influences resources of vegetative regulation. Course introduction of a korteksin (10 injections) leads to improvement of indicators of physical working capacity (lengthening of time of swimming), regulation of a warm rhythm and normalization of indicators of stressful reaction. Korteksin, as we know, leads to activation of fermental system of neurons and neurotrophic factors of a brain; optimizes balance of a metabolism of exciting and brake amino acids: glutamate, dopamine, serotonin, gamma аминомасляной acids, improves bioelectric activity of a brain, prevents education of free radicals (products of lipid peroxidation). Besides, such action of a korteksin allows to understand more precisely features of dynamics and formation of processes of adaptation, a readaptation and disadaptation. Thus, use of a korteksin in the conditions of emergency situations can become important help in increase of physical working capacity, endurance and a survival of animals and, apparently, the person.

Keywords

adaptation / cold influence / painful influence / neuropeptid / stress reaction / physical working capacity / disadaptation

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