The dynamics of the electrophysiological parameters of hands nervous during hormone replacement therapy in patients with newly diagnosed hypothyroidism

Abstract

To clarify the pathogenesis of neuropathy in 20 patients with newly diagnosed primary (thyrogenous) hypothyroidism in the background of autoimmune thyroiditis electroneuromyographic study of hand nerves before and after the start of hormone replacement therapy was conducted. At the beginning of the study, all patients were diagnosed with manifest hypothyroidism. The serum levels of thyroid stimulating hormone were elevated, and the concentration of free thyroxin was reduced. At the end of the study (after 6 months), the concentration of thyroid stimulating hormone and free thyroxine in the blood serum were within reference values, which indicated the effectiveness of treatment of hypothyroidism. During electroneuromyographic examination before treatment in 5 patients were recorded normal levels compared to normative data by age and sex. In 15 recorded the data for violation of the sensory fibers. Data for breach of conduct has not been received by the motor fibers. After 6 months of starting hormone replacement therapy data for violation of the sensory and motor fibers had been received from 14 of 20 patients. 6 noted the positive dynamics of electroneuromyography. The lateralization of the severity of the lesions of the nerve fibers depended on the leading arm. Thus, the decrease in the amplitude of the sensory potential of the median was more pronounced in the right, leading arm. For the ulnar nerve, this dependence of the lateralization of the lesion was not detected.

With this stimulus electroneuromyography been identified primary lesion of nerves and clarify the role of the effect of hormone replacement therapy on the development of neuropathies.

Keywords

entrapment neuropathy / hypothyroidism / stimulation electroneuromyography / polyneuropathy / median nerve / ulnar nerve / replaceable hormonal therapy / free thyroxine / thyritropic hormone

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