Role chemokines in development of the immune answer

Abstract

The basic biological effects of viruses which allow them to leave from immune supervision, and also feature of development antiviral the immune answer are resulted. The role of natural killers, cytotoxic T-lymphocyte, T-killers, macrophages is characterized. It was established that the concrete virus co-operates only with certain receptors; on a cage there can be receptors for various types of viruses; receptors for a certain virus can be on cages of various types. On this background the characteristic of the cores chemokines, intimate mechanisms providing development antiviral the answer is given. It is revealed that biological activity chemokines is regulated by receptors which contact several fibers which belong either to group CC-chemokines, or to group CXC-chemokines. Chemokines homologous among themselves can contact the same receptors. It is shown that chemokines receptor CXCR 4 provides human immunodeficiency virus penetration, sensuous to T-cages, CCR 2 – to macrophages, CCR 3 – to eosinophil cells, CCR 5 – to T-helper 1 type. Eotaxin interrupts communication of a virus with receptor CCR 3 that specifies in more important role of the last in pathogenesis infection a human immunodeficiency virus. Natural ligand macrophage-like the squirrel of an inflammation 1 and RANTES block macrophage-like infection a human immunodeficiency virus, but not an infection caused by other viruses, sensuous to T-cages. It is established that increase of the maintenance of matrix ribonucleic acid CCL 4/MIP-1 β and CCL 5/RANTES in plasma of blood at persons with a virus infection both CXCL 8/IL-8 and CCL 4/MIP-1β reflects development of an immune inflammation. Definition of an expression of matrix ribonucleic acid chemokines and chemokines receptors can be the important diagnostic sign of progressing of a virus infection. Chemokines and them transmitter are responsible for effects of cages in sites of an inflammation and directly cause activation of cages. Chemokines and their receptors are extremely important for the control of a virus infection and replication.

Keywords

cytokines / сhemokines / eotaxin / receptors / immunocompetent сells / anti-infectious immunity / human immunodeficiency virus

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