Types of aging and vegetative status in patients with erectile dysfunction in late ontogenesis

Abstract

The features of the vegetative status with different types of aging in patients with erectile dysfunction in late ontogenesis are considered. It is established that patients with erectile dysfunction in late ontogenesis, enduring their aging process according to the ontogenetic model, in contrast to patients with somatic diseases have more pronounced metabolic disturbances associated with the activity of the sympathetic nervous system. Also, patients with erectile dysfunction and age- associated diseases are more likely to complain about sleep disorders, which may be related to aging on the developmental type. Patients with age-associated diseases have significantly lower overall testosterone levels, compared with the group of patients with somatic diseases. In patients with age-associated diseases, the overall hearth rhythm energy was significantly lower compared to patients with general-somatic diseases, which indicates a decrease in the adaptive capacity of the cardiovascular system and low stress-resistance in this group of patients. In general, in patients with erectile dysfunction aging according to the ontogenetic model of aging, activation of sympathetic influences and a decrease in parasympathetic tone are noted in the vegetative status.

Keywords

vegetative status / aging / ontogenesis / erectile dysfunction / age-related hypogonadism / age-related hypogonadism / age-associated diseases / general diseases / type of aging / testosterone

References

[1] Антонян, В.В. Состояние вегетативного статуса и его корреляция в комплексном лечении больных эрозивно-язвенными заболеваниями желудка и двенадцатиперстной кишки: автореф. дис. … канд. мед. наук / В.В. Антонян. – Астрахань, 2011. – 50 с.

[2] Бабунц, И. В. Азбука вариабельности сердечного ритма / И.В. Бабунц, Э.М. Мириджанян, Э.А. Машаех. – Ставрополь, 2002. – 112 с.

[3] Вейн, А.М. Вегетативные расстройства: клиника, лечение, диагностика / А.М. Вейн. – М.: МИА, 2000. – 752 с.

[4] Всемирная Организация Здравоохранения. Доклад о ситуации в области неинфекционных заболеваний в мире. – Geneva, WHO. – 2014. – 16 с.

[5] Дедов, И.И. Возрастной андрогенный дефицит у мужчин / И.И. Дедов, С.Ю. Калинченко. – М.: Практ. медицина, 2006. – 240 с.

[6] Дильман, В.М. Четыре модели медицины / В.М. Дильман. – Л.: Медицина, 1987. – 287 с.

[7] Коркушко, О.В. Возрастные и патологические изменения суточной вариабельности сердечного ритма/ О.В. Коркушко, А.В. Писарук, В.Ю. Лишневская // Вестн. аритмологии. – 1999. – № 14. – C. 30–33.

[8] Трубин, В.Н. Пожилое население России: проблемы и перспективы / В.Н. Трубин, Н.Н. Николаева, М.Е. Палеева. – М.: Аналит. центр при поддержке Правительства РФ, 2016. – 45 с.

[9] Buccelletti, E. Heart rate variability and myocardial infarction: systematic literature review and metanalysis / E. Gilardi [et al.] // Eur. Rev. Med. Pharmacol. Sci. – 2009. – Vol. 13, № 4. – P. 299–307.

[10] Camm, A.J. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: Standards of measurement, physiological interpretation, and clinicaluse / A.J. Camm [et al.] // Circulation. – 1996. – Vol. 93. – P. 1043–1065.

[11] Heinemann, L.A.J. A new aging males symptoms (AMS) rating scale / L.A.J. Heinemann, T. Zimmermann, A. Vermeulen // Aging Male. – 1999. – Vol. 2, № 2. – P. 105–114.

[12] Lunenfeld, B. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men / B. Lunenfeld [et al.] // Aging Male. – 2015. – Vol. 18, № 1. – P. 5–15.

[13] Lim, S.S. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 / S.S. Lim [et al.] // Lancet. – 2012. – Vol. 380, № 9859. – P. 2224–2260.

[14] NIH Consensus conference. Impotence. NIH Consensus development panel on impotence. – J.A.M.A. – 1993. – Vol. 270, № 1. – P. 83–90.

[15] Rosen, R.C. The international index of erectile function (IIEF): a state- of- the-science review / R.C. Rosen, J.C. Cappelleri, N. Gendrano // Intern. J. Impot. Res. – 2002. – Vol. 14, № 4. – P. 226–244.

[16] Saigal, C.S. Predictors and prevalence of erectile dysfunctiob in a racially diverse population / C.S. Saigal, H. Wessells, J. Pace // Arch. Intern. Med. – 2006. – Vol. 166. – № 2. – P. 207–212.

[17] Shores, M.N. Low serum testosterone and mortality in male veterans / M.N. Shores // Arch. Internal Med. – 2006. – Vol. 166, № 15. – P. 1660–1665.

[18] United Nations Population Fund & Help Age International. Ageing in the Twenty-First Century: A Celebration and A Challenge. – London: Pureprint Group, 2012. – P. 8.

[19] Yang, H. The effects of aging on testicular volume and glucose metabolism: an investigation with ultrasonography and FDG- PET / H. Yang [et al.] // Molec. Imaging Biol. – 2011. – Vol. 13, № 2. – P. 391–398.

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