Disease as a result of violations of the symbiotic relationship between the host and the microbiota with pathogens

Abstract

Recent achievements in many sciences have led to an understanding of the need to form new ideas about the nature of human relationships with the environment and the inner world, his health, the principles of disease formation and their prevention. There has been a transition from a collection of achievements of various sciences to a holistic paradigm that unites a person as an organism and as a person, his inner and surrounding world. It became obvious that this could not be done within the framework of the previous general theories of medicine. To this end, the authors propose a new theory of medicine: "the theory of noospheric-anthropogenic harmony". From the standpoint of this theory, the mechanisms of the relationship of microbiota and pathogens with the protective and acceptive immunity of a healthy and sick person, as well as the mechanisms of microbiota regulation, are considered. The paradigm of dysbiosis as the cause of many diseases and main homeostatic mechanisms that provide symbiotic relationships of microbiota, immunity and its role in the mechanisms of natural tolerance and formation of various disease, such as, autoimmune ones and tumors, require a change in the acceptedtreatment and prevention. A new approach should be based on using a new class of drugs — metabiotics, which in their term influence microbiota.

Keywords

noospheric-anthropogenic harmony / diseases / microbiota / protective immunity / acceptive immunity / metabiotics / dysbiosis / prevention / treatment

References

[1] Ugolev AM. Trofologija — novaja mezhdisciplinarnaja nauka. Vestnik AN SSSR. 1980;(1):50–68. (In Russ.).

[2] Уголев А.М. Трофология — новая междисциплинарная наука // Вестник АН СССР. 1980. № 1. С. 50–68.

[3] Tkachenko EI. Teorija patologii vnutrennih organov, svjazannoj s terapevticheskimi infekcijami. Problemy teorii i praktiki obshhestvennogo i individual’nogo zdorov’ja v sovremennyh uslovijah: sbornik trudov SPbGMA im. I.I. Mechnikova. 1999;273–273. (In Russ.).

[4] Ткаченко Е.И. Теория патологии внутренних органов, связанной с терапевтическими инфекциями // Проблемы теории и практики общественного и индивидуального здоровья в современных условиях: сборник трудов СПбГМА им. И.И. Мечникова. 1999. С. 273–273.

[5] Tkachenko EI. Nutrition, human endoecology, health, diseases. current views on their relations. Terapevticheskij arhiv. 2004;76(2):67–71. (In Russ.).

[6] Ткаченко Е.И. Питание, эндоэкология, здоровье, болезни. Современный взгляд на проблему их взаимосвязей // Терапевтический архив. 2004. Т. 76, № 2. С. 67–71.

[7] Sitkin SI, Tkachenko EI, Vahitov TJa, et al. Serum metabolome and gut microbiota in ulcerative colitis and celiac disease. Vestnik Severo-Zapadnogo gosudarstvennogo medicinskogo universiteta im. I.I. Mechnikova. 2014;6(3):12–22. (In Russ.).

[8] Ситкин С.И., Ткаченко Е.И., Вахитов Т.Я. и др. Метаболом сыворотки крови и микробиота кишечника при язвенном колите и целиакии // Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова. 2014. Т. 6, № 3. С. 12–22.

[9] Kiseleva EP. Akceptivnyj immunitet — osnova simbioticheskih vzaimootnoshenij. Infekcija i immunitet. 2015;(2):1–22. (In Russ.). DOI: 10.15789/2220-7619-2015-2-113-130

[10] Киселева Е.П. Акцептивный иммунитет — основа симбиотических взаимоотношений // Инфекция и иммунитет. 2015. № 2. С. 1–22. DOI:10.15789/2220-7619-2015-2-113-130

[11] Klimovich VB, Samojlovich MP. Immunoglobulin A (IgA i ego receptory). Medicinskaja immunologija. 2006;8(4):483–500. (In Russ.). DOI: 10.15789/1563-0625-2006-4-483-500

[12] Климович В.Б., Самойлович М.П. Иммуноглобулин А (IgА и его рецепторы) // Медицинская иммунология. 2006. Т. 8, № 4. С. 483–500. doi.org/10.15789/1563-0625-2006-4-483-500.

[13] Brandtzaeg P. Secretory IgA: Designed for Anti-Microbial Defense. Front Immunol. 2013;6:4:222. doi: 10.3389/fimmu.2013.00222

[14] Brandtzaeg P. Secretory IgA: Designed for Anti-Microbial Defense // Front Immunol. 2013. Vol. 6. No. 4. P. 222. DOI: 10.3389/fimmu.2013.00222

[15] Macpherson AJ, Geuking MB, McCoy KD. Homeland security: IgA immunity at the frontiers of the body. Trends Immunol. 2012;33(4):160–167. DOI: 10.1016/j.it.2012.02.002

[16] Macpherson AJ, Geuking MB, McCoy KD. Homeland security: IgA immunity at the frontiers of the body // Trends Immunol. 2012. Vol. 33. No. 4. P. 160–167. DOI: 10.1016/j.it.2012.02.002

[17] Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12(12):821–832. DOI: 10.1038/nri3322

[18] Pabst O. New concepts in the generation and functions of IgA // Nat Rev Immunol. 2012. Vol. 12. No. 12. P. 821–832. DOI: 10.1038/nri3322

[19] Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol. 2010;28:623–667. DOI: 10.1146/annurev-immunol-030409-101330

[20] Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis // Annu Rev Immunol. 2010. Vol. 28. P. 623–667. DOI: 10.1146/annurev-immunol-030409-101330

[21] Honda K, Takeda K. Regulatory mechanisms of immune responses to intestinal bacteria. Mucosal Immunol. 2009;2(3):187–196. DOI: 10.1038/mi.2009.8

[22] Honda K, Takeda K. Regulatory mechanisms of immune responses to intestinal bacteria // Mucosal Immunol. 2009. Vol. 2. No. 3. P. 187–196. DOI: 10.1038/mi.2009.8

[23] Smith PD, Smythies LE, Shen R, et al. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 2011;4(1):31–42. DOI: 10.1038/mi.2010.66

[24] Smith PD, Smythies LE, Shen R, et al. Intestinal macrophages and response to microbial encroachment // Mucosal Immunol. 2011. Vol. 4. No. 1. P. 31–42. DOI: 10.1038/mi.2010.66

[25] Johansson MЕ., Larsson JM, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA. 2011;15:(Suppl. 1):4659–4665. DOI: 10.1073/pnas.1006451107

[26] Johansson MЕ., Larsson JM, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA. 2011. Vol. 15. No.108 (Suppl 1). P. 4659–4665. DOI: 10.1073/pnas.1006451107

[27] Hooper LV, Stappenbeck TS, Hong CV, Gordon JI. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003;4(3):269–273. DOI: 10.1038/ni888

[28] Hooper LV, Stappenbeck TS, Hong CV, Gordon JI. Angiogenins: a new class of microbicidal proteins involved in innate immunity // Nat Immunol. 2003. Vol. 4. No. 3. P. 269–273. DOI: 10.1038/ni888.

[29] Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA. 2002;26:99(24):15451–15455. DOI: 10.1073/pnas.202604299

[30] Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells // Proc Natl Acad Sci USA. 2002. Vol. 26. No. 99(24). P. 15451–15455. DOI: 10.1073/pnas.202604299

[31] Brown EM, Sadarangani M, Finlay BB. The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol. 2013;14(7):660–667. DOI: 10.1038/ni.2611

[32] Brown EM, Sadarangani M, Finlay BB. The role of the immune system in governing host-microbe interactions in the intestine // Nat Immunol. 2013. Vol. 14. No. 7. P. 660–667. DOI: 10.1038/ni.2611

[33] Domaradskij IV, Hohoev TH, Kondrakova OA, et al. Protivorechivaja mikrojekologija. Rossijskij himicheskij zhurnal. 2002; HLVI(3):81–88. (In Russ.).

[34] Домарадский И.В., Хохоев Т.Х., Кондракова О.А. и др. Противоречивая микроэкология // Российский химический журнал. 2002. Т. XLVI, № 3. С. 81–88.

[35] Shenderov BA. Funkcional’noe pitanie i ego rol’ v profilaktike metabolicheskogo sindroma. Moscow: Deli print; 2008; 319 р. (In Russ.).

[36] Шендеров Б.А. Функциональное питание и его роль в профилактике метаболического синдрома. М.: Дели принт, 2008. 319 с.

[37] Stehin AA, Jakovleva GV, Iksanova TI, et al. Voprosy elektronnoj kinetiki organospecificheskih preparatov. Teorija i praktika primenenija innovacionnyh nelekarstvennyh preparatov PawerMatrix v sisteme profilaktiki i integrativnoj mediciny: Sbornik materialov I i II mezhdunarodnoj nauchno-prakticheskoj konferencii. Moscow; 2018:6–18. (In Russ.).

[38] Стехин А.А., Яковлева Г.В., Иксанова Т.И. и др. Вопросы электронной кинетики органоспецифических препаратов // Теория и практика применения инновационных нелекарственных препаратов PowerMatrix в системе профилактики и интегративной медицины: сборник материалов I и II международной научно-практической конференции. М., 2018. С. 6–18.

[39] Shenderov BA, Tkachenko EI, Lazebnik LB, et al. Мetabiotics — novel technology of protective and treatment of diseases associated with microecological imbalance in human being. Eksperimental’naya i klinicheskaya gastroenterologiya. 2018;151(3):83–92.

[40] Шендеров Б.А., Ткаченко Е.И., Лазебник Л.Б. и др. Метабиотики — новая технология профилактики и лечения заболеваний, связанных с микроэкологическими нарушениями в организме человека // Экспериментальная и клиническая гастроэнтерология. 2018. № 151 (3). С. 83–92.

RIGHTS & PERMISSIONS

Tkachenko E.I., Grinevich V.B., Gubonina I.V., Kravchuk Y.A., Apcel V.Y., Ivanyuk E.S.