Immunoprotective therapy of suppression of humoral immune response, pain induced (search for narcotic analgesics with immunoprotective activity)
V. N. Aleksandrov , A. A. Kondratenko , E. V. Mikhailova , S. V. Kromsky , V. S. Sidorin , L. P. Sigareva , M. I. Eliseeva , V. A. Gorichny , N. V. Pak , P. A. Slizhov
Bulletin of the Russian Military Medical Academy ›› 2020, Vol. 22 ›› Issue (2) : 122 -124.
Immunoprotective therapy of suppression of humoral immune response, pain induced (search for narcotic analgesics with immunoprotective activity)
Problematic issues of prevention of humoral immune response suppression induced by pain in conditions of the experimental model of severe mechanical trauma are highlighted. It has been established that one of the pathogenetic factors of trauma depressing the humoral immune response is pain. Thus, drugs inhibiting intra-central transmission of afferent impulse, and, in particular, narcotic analgesics, may be considered as drugs with immunoprotective activity. Evaluation of the immunoprotective activity of five narcotic analgesics administered immediately after trauma to immunized mice in the first 24 hours of post-traumatic period showed the presence of the estimated effect in morphine hydrochloride, fentanyl and pifurben. By 106 splenocytes of mice received these preparations and immunized on the first day after the trauma, reliably more antibodies forming cells are formed in mice in comparison with their number in animals received after the trauma as narcotic analgesics intermediol and dipidolor. Thus, morphine hydrochloride, fentanyl and pifurben, i.e. drug analgesics with immunoprotective activity, should be considered as the preferred drugs in the group of narcotic analgesics in emergency care for patients with severe trauma. The use of narcotic analgesics with immunoprotective properties should be considered as one of the measures in the complex of measures aimed at the prevention of post-traumatic immunodeficiency and infection in an immunocompromised host. Infections are difficult to diagnose and often with an unfavorable outcome.
injur y / shock / pain / secondar y immune deficiency / infection / immune response / drug analgesic / immunoprotective activity / antibodies forming cells
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Aleksandrov V.N., Kondratenko A.A., Mikhailova E.V., Kromsky S.V., Sidorin V.S., Sigareva L.P., Eliseeva M.I., Gorichny V.A., Pak N.V., Slizhov P.A.
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