Possibilities of transient and two-dimensional shear wave elastography in the diagnosis of fibrosis in nonviral chronic diffuse liver diseases in military personnel

Abstract

The study examines the possibilities of transient and two-dimensional shear wave elastography in the diagnosis of fibrosis in the most common chronic diffuse liver diseases of non-viral etiology: alcoholic and non-alcoholic fatty liver disease, as well as their combination. It was found that in patients suffering from these diseases, the values of aspartate and alanine aminotransferase, gamma-glutamyl transpeptidase, cholesterol, triglycerides, as well as the oblique vertical size of the right lobe of the liver were significantly (p<0,05) higher than in patients of the control group. Moreover, most of these indicators reliably (p<0,01) reached the highest values in patients suffering from fatty liver disease of alcohol-metabolic etiology, which confirms a more pronounced damaging effect on the liver with a combination of alcohol and metabolic factors. It has been established that the use of transient and two-dimensional elastography is characterized by high diagnostic significance in determining the stage of fibrosis in chronic diffuse liver diseases of non-viral etiology. The greatest diagnostic significance of elastographic research methods is noted in the third and fourth stages of fibrosis. In the second stage of fibrosis, the quality of diagnostic significance when using transient elastography was higher than when using two-dimensional shear wave. The use of transient and two-dimensional shear wave elastography in most cases avoids liver biopsy in patients suffering from chronic diffuse liver diseases of non-viral etiology. Therefore, in the diagnosis of chronic diffuse liver diseases, the presence and degree of fibrosis is a factor that will largely determine the prognosis, treatment tactics and the likelihood of complications in a particular patient.

Keywords

chronic diffuse liver disease of non-viral etiology / non-alcoholic fatty liver disease / alcoholic liver disease / fatty liver disease of alcohol-metabolic etiology / liver fibrosis / non-invasive diagnosis of liver fibrosis / transient elastography / two-dimensional shear wave elastography / diagnostic significance

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RIGHTS & PERMISSIONS

Zhirkov I.I., Gordienko A.V., Yakovlev V.V., Serdyukov D.Y., Dorohov G.Y., Vashchenkov V.V., Brynyuk A.S., Shichkin M.F.