Chronic inflammation and premature aging – two parallel processes in polymorbid cardiovascular pathology

Abstract

Premature aging in young and middle-aged men suffering from polymorbid cardiovascular disease. It was established that it was 7,53±2,02 mg/l (in healthy people it was 0,65±0,24 mg/l), tumor necrosis factor-α 34,3±4,85 pg/ml (in healthy people – 7,69±4,6), interleukin-1β 5,14±2,08 pg/ml, interleukin-6 10,99±5,7 pg/ml (in healthy people – 2,23±1,27; 4,39±0,77), against the background of low anti-inflammatory activity – interleukin-4 10,99±5,7 pg/ml, interleukin-10 2,6±1,79 pg/ml (in healthy people – 7,42±1,19; 32,34±7,51). In patients with polymorbid cardiovascular system pathology there was an increase in anxiety and depression, a decrease in working capacity against the background of increasing the tone of the autonomic nervous system. When assessing the rate of aging in the group of patients, an increase in the biological age and functional class of aging was noted – 54,5±3,15 years and the V-worst class. Thus, we were able to establish that in young and middle-aged men with polymorbid cardiovascular system pathology, high C-reactive protein titer, along with altered immuno-inflammatory response, are the most important factor in maintaining chronic inflammation in the body, which determines the progression of endothelial dysfunction, systemic atherosclerosis and, as a result, an increased risk of cardiovascular events. The reactivity of the immune system in the absence of an active inflammatory focus in this category of persons is due to inflamming, which initiates premature aging of the body.

Keywords

premature aging / chronic inflammation / interleukins / C-reactive protein / tumor necrosis factor-α / polymorbid cardiovascular pathology / immune system reactivity / endothelial dysfunction

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RIGHTS & PERMISSIONS

Parcernyak A.S., Khalimov Yu.Sh.