Pituitary-gonadal system as an indicator of the functional state of the male reproductive system under the influence of stress factors

Abstract

The functional state of the pituitary-gonadal system in men is evaluated on the background of risk factors. It has been established that men who carry out their work at chemically hazardous objects (destruction zones, storage facilities for highly toxic chemicals) are subject to the combined effects of stress factors in the working environment. The pituitary-gonadal system, which is the basis of the reproductive function of the body and is based on complex hormonal regulation, is one of the most vulnerable systems. It’s normal functioning in men is mediated by the interaction of the main pituitary hormones and testosterone. The main factors of chemically hazardous objects due to the specifics of the work performed on them are: overheating, physical exertion, desynchronosis, and tension. It is assumed that the negative effects of the action of the factors of the working environment can be mediated both by their direct impact on the male gonad and by affecting the secretion of gonadotropins by the adenohypophysis. The effect of a complex of stress factors leads to the formation in men involved in the destruction and storage of highly toxic chemicals a relative androgen deficiency in combination with hyperprolactinemia and an increase in gonadotropin levels. At the same time, the greatest decrease in testosterone in the blood is observed in men working at the sites of destruction than in people working in the storage warehouses of highly toxic chemicals of the same age category. The relative androgen deficiency in personnel of chemically hazardous objects is transient in nature. Termination of work with highly toxic chemicals for a period of up to 14 days leads to a significant increase in the total testosterone in the blood of men.

Keywords

androgen deficiency / stress factors / chemically dangerous object / testosterone / prolactin / gonadotropins / adenohypophysis / reproductive system / highly toxic chemicals

References

[1] Гриффин, Д.Е. Мужская репродуктивная функция. Физиология эндокринной системы / Д.Е. Гриффин, С. Охеда. – М.: Бином, 2008. – С. 277–304.

[2] Дедов, И.И. Рекомендации по диагностике и лечению гипогонадизма (дефицита тестостерона) у мужчин: проект. Федеральные клинические рекомендации / И.И. Дедов [и др.] // Пробл. эндокринологии. – 2015. – № 5. – С. 60–71.

[3] Рыжакова, Д.И. Влияние внешних факторов на мужскую репродуктивную систему / Д.И. Рыжакова. – Н. Новгород: НГМА, 2006. – 28 с.

[4] Cameron, J.L. Stress and behaviorally induced reproductive dysfunction in primates / J.L. Cameron // Semin. Reprod. Endocrinol. – 1997. – Vol. 15. – P. 37–45.

[5] Diaz, S. Circadian variation of basal plasma prolactin, prolactin response to suckling, and length of amenorrhea in nursing women / S. Diaz. [et al.] // J. Clin. Endocrinol. Metab. – 1989. – Vol. 68. – P. 946–955.

[6] Lachelin, G. C. Hypothalamic chronic anovulation / G.C. Lachelin, S.S. Yen // Am. J. Obstet. Gynecol. – 1978. – Vol. 130. – P. 825–831.

[7] Pechersky, А.V. Role of Partial Androgen Deficiency of Aging Men in development of the metabolic syndrome / А.V. Pechersky // American research journal of urology. – 2016. – Vol. 1. – P. 1–13.

[8] Rsmussen, K., A genotoxic study of metal workers exposed to trichloroethylene: sperm parameters and chromosome aberrations in lymphocytes / K. Rsmussen [et al.] // Int Arch Occup. Environ. Health. – 2000. – Vol. 2. – P. 419–423.

[9] Shimatsu, A. Involvment of hypothalamic vasoactiv intestinal polypeptide (VIP) in prolactin secretion induced by serotonin in rats / A. Shimatsu [et al.] // Proc. Soc. Biol. Med. – 1984. – Vol. 175. – P. 414–416.

RIGHTS & PERMISSIONS

Zaytsev V.A., Khalimov Yu.Sh., Zhekalov A.N.