Results of the morphological research of brain tissue in idiopathic normal pressure hydrocephalus

Abstract

Idiopathic normal pressure hydrocephalus is a chronic brain disease of elderly, which leads to severe disability in case of inadequate treatment. Despite a number of experimental, morphological and clinical trials, the pathogenesis of the normal pressure hydrocephalus remains unclear. Microstructural changes in brain tissue due to normal pressure hydrocephalus described. Most often pathological features of idiopathic normal pressure hydrocephalus are: exhaustion of brain tissue, enlargement of perivascular spaces, aseptic necrosis, and amyloid and Lewy body’s formation presented. Investigated changes in brain tissue of patients with idiopathic normal pressure hydrocephalus transform our views on its mechanisms. It becomes clear that idiopathic normal pressure hydrocephalus is a part of a common neurodegenerative process that has exclusive features in any case.

Keywords

normal pressure hydrocephalus / pathogenesis / pathomorphology / brain biopsy / Alzheimer disease / microscopy / amyloid angiopathy / dementia / degenerative diseases / perivascular spaces / electron microscopy / neuropathology

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RIGHTS & PERMISSIONS

Gavrilov G.V., Stanishevskiy A.V., Gaydar B.V., Paramonova N.M., Gaykova O.N., Svistov D.V.