Lipid status and vascular bloodstream of servicemen with initial liver fibrosis

Abstract

Frequency of violations of nutritional status, lipid metabolism, cardiovascular status and large vessels endothelium changes in servicemen with fatty liver dystrophy and early fibrosis are assessed. It is revealed that the prevalence of hepatic pathology with dysmetabolic aetiology in this category has vary from 41 to 67%, increasing in combination with subclinical atherosclerosis. According to the results of the study, it is found out that the fibrotic changes in the liver of servicemen associated with a higher frequency of abdominal obesity (higher body mass index and waist circumference), dyslipidemia and structural atherogenic changes of common carotid arteries intima-media complex by type of subclinical atherosclerosis. Have been determined that a violation of the liver elasticity revealed during conducting of transient elastography on servicemen with initial fibrosis meets I-II stage. In the same group with biochemical study increased hepatic biochemical parameters of cytolysis and cholestasis that may indicate activation of inflammatory reactions and transition from fatty hepatosis to more severe stage of steatohepatitis are revealed. A possible mechanism of relationship of obesity, liver fibrosis and atherosclerotic changes of endothelium is proposed. A primary role of fibrosis in nonalcoholic fatty liver disease as a risk factor for the progression of hepatic and cardiovascular pathology in young men was determined.

Keywords

liver elasticity / nonalcoholic fatty liver disease / steatohepatitis / dyslipidemia / atherosclerosis / elastography / servicemen / ultrasound carotid examination

References

[1] Бацков, С.С. Неалкогольная жировая болезнь поджелудоч- ной железы как дигестивный маркер метаболического синдрома / С.С. Бацков, Г.А. Пронина, Д.И. Инжеваткин // Мед.-биол. и соц.-психол. проблемы безопасности в чрез- вычайных ситуациях. - 2012. - № 4. - С. 50-55.

[2] Денисов, Н.Л. Неалкогольная жировая болезнь печени как новая компонента метаболического синдрома в свете со- временных методов диагностики / Н.Л. Денисов [и др.] // Вестн. Сев.-Зап. гос. мед. университета им. И.И. Мечнико- ва. - 2017. - Т. 9, № 1. - С. 34-41.

[3] Ивашкин, В.Т. Распространенность неалкогольной жировой болезни печени у пациентов амбулаторно-поликлиниче- ской практики в Российской Федерации: результаты ис- следования DIREG 2 / В.Т. Ивашкин [и др.] // Росc. журн. гастроэнтерологии, гепатологии, колопроктологии. - 2015. - № 6. - 31-41.

[4] Сердюков, Д.Ю. Основные и дополнительные маркёры риска сердечно-сосудистых заболеваний у военнослужащих- мужчин молодого и среднего возраста с начальными атеросклеротическими изменениями сосудистой стенки / Д.Ю. Сердюков // Тихоокеан. мед. журн. - 2017. - № 2. - С. 65-69.

[5] Catanzaro, R. Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease / R. Catanzaro [et al.] // World J. Gastroenterol. - 2016. - № 22 (34). - P. 7660-7675.

[6] Chalasani, N. The diagnosis and management of nonalcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the study of liver diseases, and American College of Gastroenterology / N. Chalasani [et al.] // Gastroenterology. - 2012. - № 142. - P. 1592-1609.

[7] Farcaş, A.D. Nonalcoholic fatty liver disease, bulb carotid intima-media thickness and obesity phenotypes: results of a prospective observational study / A.D. Farcaş1, C.L. Vonica, A.C. Golea // Med. Ultrason. - 2017. - Vol. 19, № 3. - P. 265-271.

[8] Huh, J.H. Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status / J.H. Huh [et al.] // Metabolism. - 2017. - Vol. 66. - P. 23-31.

[9] IDF Consensus Worldwide Definition of the Metabolic Syndrome // International Diabetes Federation. - Brussels, Belgium. - 2006. - 24 p.

[10] Kitade, H. Nonalcoholic fatty liver disease and insulin resistance: new insights and potential new treatments / H. Kitade [et al.] // Nutrients. - 2017. - № 9. - P. 2-13.

[11] Mikolasevic, I. Nonalcoholic fatty liver disease - a multisystem disease? / I. Mikolasevic [et al.] // World J. Gastroenterol. - 2016. - Vol. 22, № 43. - P. 9488-9505.

[12] Patil, R. Nonalcoholic fatty liver disease and cardiovascular risk / R. Patil, G.K. Sood // World J. Gastrointest. Pathophysiol. - 2017. - № 8 (2). - P. 51-58.

[13] WMA Declaration of Helsinki - Ethical principles for research involving human subjects. - Brasil, 2013. - 21 р.

RIGHTS & PERMISSIONS

Gordienko A.V., Zhirkov I.I., Serdyukov D.Y.