Changes in clinical condition and quality of life of patients with involutional changes of facial skin and metabolic syndrome after the course of treatment with therapeutic physical factors

Abstract

BACKGROUND: The presence of concomitant chronic non-infectious diseases, which significantly increase in probability and severity with age, contributes to the intensity of external manifestations of involutional processes. This is absolutely true for the metabolic syndrome, which is confirmed to be associated with involutional changes in the skin and soft tissues of the face through systemic mechanisms of comorbidity, determining mutual additive influences.

AIM: The aim of the study was to evaluate the clinical efficacy of the combined use of transcranial magnetic field therapy, oxygen bar therapy, and laser phoresis of hyaluronic acid for the treatment of involutional skin changes in patients with metabolic syndrome.

MATERIALS AND METHODS: Using a simple randomization technique, patients with involutional skin changes associated with metabolic syndrome (n=120) were divided into 4 groups of 30 subjects each. Subjects in group 1 (control group) received only laser phoresis of hyaluronic acid; subjects in group 2 (comparator group 1) received one course of transcranial magnetic therapy; subjects in group 3 (comparator group 2) received one course of oxygen bar therapy; subjects in group 4 (experimental group) received one course of combined treatment (laser phoresis of hyaluronic acid + transcranial magnetic therapy + oxygen bar therapy). Results were evaluated based on changes in the severity of key clinical and functional signs of age-related skin changes. In addition, the quality of life of the patients was evaluated using the Dermatologic Index, and the overall aesthetic improvement was evaluated using the Global Aesthetic Improvement Scale (GAIS).

RESULTS: The comorbidity of chronoaging with metabolic syndrome is associated with subjectively more severe major clinical manifestations of facial skin aging and indicative changes in its morphological and functional parameters. A comparative analysis of the effectiveness of using different monotherapy regimens showed the most significant regression of clinical manifestations with the laser phoresis of hyaluronic acid. The total subjective score of major clinical manifestations of age-related skin changes decreased by 39.8% on a visual analog scale (VAS), and the quality of life increased by 61.7%. The GAIS score was 2.48. Visual analog scale scores were largely consistent with changes in objective skin parameters. In the transcranial magnetic therapy and oxygen bar therapy groups, the effect was weaker and almost equal. The highest efficacy was reported in the experimental group: regression of clinical manifestations of skin chronoaging and restoration of objective dermal parameters were reliable and exceeded the level of the control group after the treatment.

CONCLUSION: The combined treatment shows a significant increase in clinical efficacy due to the pathogenetic effect on the metabolic syndrome. Sinergy of therapeutic physical factors is achieved by different modalities, sites of treatment, and mechanisms of biological potential.

Keywords

involutional skin changes / corneometry / laser phoresis of hyaluronic acid / metabolic syndrome / oxygen bar therapy / transcranial magnetic therapy / tevametry / elastometry

References

[1] Ayvazyan TA, Alexandrova IE, Anufrieva EV, et al. Health of a healthy person. 3rd ed., revised and updated. Moscow: International University of Regenerative Medicine; 2016. 624 р. (In Russ.)

[2] Айвазян Т.А., Александрова И.Э., Ануфриева Е.В., и др. Здоровье здорового человека. 3-е изд., перераб. и доп. Москва: Международный университет восстановительной медицины, 2016. 624 с.

[3] Blokzijl F, de Ligt J, Jager M, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature. 2016;538(7624):260–264. EDN: XULDOD doi: 10.1038/nature19768

[4] Blokzijl F., de Ligt J., Jager M., et al. Tissue-specific mutation accumulation in human adult stem cells during life // Nature. 2016. Vol. 538, N 7624. P. 260–264. EDN: XULDOD doi: 10.1038/nature19768

[5] Reilly MJ, Tomsic JA, Fernandez SJ, Davison SP. Effect of facial rejuvenation surgery on perceived attractiveness, femininity, and personality. JAMA Facial Plast Surg. 2015;17(3):202–207. doi: 10.1001/jamafacial.2015.0158

[6] Reilly M.J., Tomsic J.A., Fernandez S.J., Davison S.P. Effect of facial rejuvenation surgery on perceived attractiveness, femininity, and personality // JAMA Facial Plast Surg. 2015. Vol. 17, N 3. P. 202–207. doi: 10.1001/jamafacial.2015.0158

[7] Swift A, Liew S, Weinkle S, et al. The facial aging process from the “inside out”. Aesthet Surg J. 2021;41(10):1107–1119. doi: 10.1093/asj/sjaa339

[8] Swift A., Liew S., Weinkle S., et al. The facial aging process from the “inside out” // Aesthet Surg J. 2021. Vol. 41, N 10. P. 1107–1119. doi: 10.1093/asj/sjaa339

[9] Kotenko KV, Eremin II, Moroz BB, et al. CELL Technologies in the treatment of radiation burns: Experience Burnasyan federal medical biophysical centre. Kletochnaya transplantologiya i tkanevaya inzheneriya. 2012;7(2):97–102. EDN: PATDYX

[10] Котенко К.В., Еремин И.И., Мороз Б.Б., и др. Клеточные технологии в лечении радиационных ожогов: опыт ФМБЦ им. А.И. Бурназяна // Клеточная трансплантология и тканевая инженерия. 2012. Vol. 7, N 2. С. 97–102. EDN: PATDYX

[11] Zhang S, Duan E. Fighting against skin aging: The way from bench to bedside. Cell Transplant. 2018;27(5):729–738. doi: 10.1177/0963689717725755

[12] Zhang S., Duan E. Fighting against skin aging: The way from bench to bedside // Cell Transplant. 2018. Vol. 27, N 5. P. 729–738. doi: 10.1177/0963689717725755

[13] Gerth DJ. Structural and volumetric changes in the aging face. Facial Plast Surg. 2015;31(1):3–9. EDN: SNBMZS doi: 10.1055/s-0035-1544252

[14] Gerth D.J. Structural and volumetric changes in the aging face // Facial Plast Surg. 2015. Vol. 31, N 1. P. 3–9. EDN: SNBMZS doi: 10.1055/s-0035-1544252

[15] Khetpal S, Ghosh D, Roostaeian J. Innovations in skin and soft tissue aging: A systematic literature review and market analysis of therapeutics and associated outcomes. Aesthetic Plast Surg. 2023;47(4):1609–1622. EDN: JIMTQK doi: 10.1007/s00266-023-03322-1

[16] Khetpal S., Ghosh D., Roostaeian J. Innovations in skin and soft tissue aging: A systematic literature review and market analysis of therapeutics and associated outcomes // Aesthetic Plast Surg. 2023. Vol. 47, N 4. P. 1609–1622. EDN: JIMTQK doi: 10.1007/s00266-023-03322-1

[17] Tarasova OV. Comparative evaluation of the effectiveness of laser technologies in the correction of involutional changes of facial skin in patients with diabetes mellitus [dissertation abstract]: 14.03.11. Place of defence: Central State Medical Academy of the Administration of Affairs of the President of the Russian Federation. Moscow; 2019. (In Russ.)

[18] Тарасова О.В. Сравнительная оценка эффективности лазерных технологий в коррекции инволютивных изменений кожи лица у пациентов с сахарным диабетом: Автореф. дис. … канд. мед. наук: 14.03.11. Место защиты: Центральная государственная медицинская академия Управления делами Президента Российской Федерации. Москва, 2019.

[19] Danilov AA, Mikhailova AA, Edelev DA, Tyan VV. Involutive skin changes in the background metabolic syndrome ― prerequisites for the development of complex physiotherapeutic influence (part 1). Russ J Environmental Rehab Med. 2023;(3):52–59. EDN: MKWLYR

[20] Данилов А.А., Михайлова А.А., Еделев Д.А., Тян В.В. Инволютивные изменения кожи на фоне метаболического синдрома ― предпосылки для разработки комплексного физиотерапевтического воздействия (часть I) // Russ J Environmental Rehab Med. 2023. № 3. С. 52–59. EDN: MKWLYR

[21] Danilov AA, Mikhailova AA, Edelev DA, Tyan VV. Involutive skin changes in the background metabolic syndrome ― prerequisites for the development of complex physiotherapeutic influence (part 2). Russ J Environmental Rehab Med. 2023;(4):40–47. EDN: BLTJKZ

[22] Данилов А.А., Михайлова А.А., Еделев Д.А., Тян В.В. Инволютивные изменения кожи на фоне метаболического синдрома ― предпосылки для разработки комплексного физиотерапевтического воздействия (часть II) // Russ J Environmental Rehab Med. 2023. № 4. С. 40–47. EDN: BLTJKZ

[23] Nizamutdinova R, Khasanova RY, Sagitova RR, et al. Metabolic syndrome as a risk factor for premature aging. In: Actual issues of human ecology: A collection of scientific articles of participants of the All-Russian scientific and practical conference with international participation: in 3 volumes. Vol. 2. Ufa: Research Centre for Information and Legal Technologies; 2015. Р. 100–105.

[24] Низамутдинова Р.С., Хасанова Р.Ю., Сагитова Р.Р., и др. Метаболический синдром как фактор риска преждевременного старения // Актуальные вопросы экологии человека: сборник научных статей участников Всероссийской научно-практической конференции с международным участием: в 3-х томах. Т. 2. Уфа: Исследовательский центр информационно-правовых технологий, 2015. С. 100–105.

[25] Glagoleva EN, Sidorov VV, Podoplekina ND, Faizullina DR. Evaluation of microcirculatory tissue systems after cosmetic procedures. Regional Blood Circulation Microcirculation. 2020;19(3):25–30. EDN: BAUZQW doi: 10.24884/1682-6655-2020-19-3-25-30

[26] Глаголева Е.Н., Сидоров В.В., Подоплекина Н.Д., Файзуллина Д.Р. Оценка микроциркуляторно-тканевых систем после косметологических процедур, направленных на коррекцию возрастных изменений // Регионарное кровообращение и микроциркуляция. 2020. Т. 19, № 3. С. 25–30. EDN: BAUZQW doi: 10.24884/1682-6655-2020-19-3-25-30

[27] Protasoni M, Serrano M. Targeting mitochondria to control ageing and senescence. Pharmaceutics. 2023;15(2):352. EDN: OYQVOW doi: 10.3390/pharmaceutics15020352

[28] Protasoni M., Serrano M. Targeting mitochondria to control ageing and senescence // Pharmaceutics. 2023. Vol. 15, N 2. P. 352. EDN: OYQVOW doi: 10.3390/pharmaceutics15020352

[29] Klemo V, Perišić MM, Štorga M, et al. Epigenetics insights from perceived facial aging. Clin Epigenetics. 2023;15(1):176. EDN: XTJHLD doi: 10.1186/s13148-023-01590-x

[30] Klemo V., Perišić M.M., Štorga M., et al. Epigenetics insights from perceived facial aging // Clin Epigenetics. 2023. Vol. 15, N 1. P. 176. EDN: XTJHLD doi: 10.1186/s13148-023-01590-x

[31] Hajam YA, Rani R, Ganie SY, et al. Oxidative stress in human pathology and aging: Molecular mechanisms and perspectives. Cells. 2022;11(3):552. EDN: CJVEAV doi: 10.3390/cells11030552

[32] Hajam Y.A., Rani R., Ganie S.Y., et al. Oxidative stress in human pathology and aging: molecular mechanisms and perspectives // Cells. 2022. Vol. 11, N 3. P. 552. EDN: CJVEAV doi: 10.3390/cells11030552

[33] Chen B, Yang J, Song Y, et al. Skin immunosenescence and type 2 inflammation: A mini-review with an inflammaging perspective. Front Cell Dev Biol. 2022;10:835675. EDN: USNHJO doi: 10.3389/fcell.2022.835675

[34] Chen B., Yang J., Song Y., et al. Skin immunosenescence and type 2 inflammation: A mini-review with an inflammaging perspective // Front Cell Dev Biol. 2022. Vol. 10. P. 835675. EDN: USNHJO doi: 10.3389/fcell.2022.835675

[35] Unnikrishnan A, Freeman WM, Jackson J, et al. The role of DNA methylation in epigenetics of aging. Pharmacol Ther. 2019;195:172–185.

[36] Unnikrishnan A., Freeman W.M., Jackson J., et al. The role of DNA methylation in epigenetics of aging // Pharmacol Ther. 2019. Vol. 195. P. 172–185.

[37] Kolesnichenko PL. Life safety: textbook. Moscow: GEOTAR-Media; 2017. 544 р. (In Russ.)

[38] Колесниченко П.Л. Безопасность жизнедеятельности: учебник. Москва, ГЭОТАР-Медиа, 2017. 544 с.

[39] Alenichev AY, Bragina IY, Bochkova NV, Tarasova OV. Involute changes of skin: Current trends of use of physiotherapeutic technologies. Physiotherapist = Fiziotherapeutist. 2018;(4):50–57. EDN: XZDIBV

[40] Аленичев А.Ю., Брагина И.Ю., Бочкова Н.В., Тарасова О.В. Инволютивные изменения кожи: современные тенденции применения физиотерапевтических технологий // Физиотерапевт. 2018. № 4. С. 50–57. EDN: XZDIBV

[41] Kolsanova OA, Suslin SA. Modern problems of the organization of the use of hardware in cosmetology clinics. Curr Problems Health Care Med Statist. 2023;(2):648–665. EDN: YUBYMU doi: 10.24412/2312-2935-2023-2-648-665

[42] Колсанова О.А., Суслин С.А. Современные проблемы организации применения аппаратных средств в клиниках косметологии // Современные проблемы здравоохранения и медицинской статистики. 2023. № 2. С. 648–665. EDN: YUBYMU doi: 10.24412/2312-2935-2023-2-648-665

[43] Kruglova LS, Tarasova OV, Rzhevskaya LV. Use of laser therapy for patients with involute changes of skin against the background of a diabetes mellitus 2 types. Physiotherapist = Fiziotherapeutist. 2019;(4):30–57. EDN: EIDIJR

[44] Круглова Л.С., Тарасова О.В., Ржевская Л.В. Применение лазеротерапии у пациентов с инволютивными изменениями кожи на фоне сахарного диабета 2 типа // Физиотерапевт. 2019. № 4. С. 30–57. EDN: EIDIJR

[45] Yusova JY. High intensity laser technology in a complex correction involutive skin changes. Physiotherapist = Fiziotherapeutist. 2015;(5):37–42. EDN: UKFKVN

[46] Юсова Ж.Ю. Высокоинтенсивные лазерные технологии в комплексной коррекции инволютивных изменений кожи // Физиотерапевт. 2015. № 5. С. 37–42. EDN: UKFKVN

[47] Yusova ZY, Baranova EL, Demidion DV, Kruglova LS. Phonophoresis with hyaluronic acid and laser technologies in correction of skin involution. Plastic Surg Aesthetic Med = Plasticheskaya Khirurgiya i Esteticheskaya Meditsina. 2023;(2):63–66. EDN: BXCEXK doi: 10.17116/plast.hirurgia202302163

[48] Юсова Ж.Ю., Баранова Е.Л., Демидион Д.В., и др. Фонофорез с гиалуроновой кислотой и лазерные технологии в коррекции инволютивных изменений кожи // Пластическая хирургия и эстетическая медицина. 2023. № 2. С. 63–66. EDN: BXCEXK doi: 10.17116/plast.hirurgia202302163

[49] Demidion DV. Interference of pulsed light and high-intensity selective laser technologies in correction of involutional changes of facial skin [dissertation abstract]: 3.1.33. Place of defence: Tsentral’naya gosudarstvennaya meditsinskaya akademiya. Moscow; 2023. 151 р. (In Russ.)

[50] Демидион Д.В. Интерференция импульсных световых и высокоинтенсивных селективных лазерных технологий в коррекции инволютивных изменений кожи лица: 3.1.33. Дис. … канд. мед. наук. Место защиты: Центральная государственная медицинская академия. Москва, 2023. 151 с.

[51] Recommendations for the management of patients with metabolic syndrome. Clinical Recommendations. Moscow; 2013. 43 р. (In Russ.)

[52] Рекомендации по ведению больных с метаболическим синдромом. Клинические рекомендации. Москва, 2013. 43 с.

[53] Moskvin SV, Geinitz AV, Khazov MB, et al. Laser phoresis of hyaluronic acid and laser cosmetology programmes (LASMIC technology). Moscow-Tver: Triada; 2010. 96 р. (In Russ.)

[54] Москвин С.В., Гейниц А.В., Хазов М.Б., Федорищев И.А. Лазерофорез гиалуроновой кислоты и лазерные косметологические программы (технология ЛАЗМИК). Москва-Тверь: Триада, 2010. 96 с.

[55] Uiba VV, Kotenko KV, Kolbakhova SN. The latest technologies of restorative medicine for the treatment of occupational lung diseases. In: The First All-Russian Congress of Doctors of Restorative Medicine: Materials congress, 27 February–01 March. Moscow; 2007. 282 p. (In Russ.) EDN: QBOLBV

[56] Уйба В.В., Котенко К.В., Колбахова С.Н. Новейшие технологии восстановительной медицины для лечения профессиональных заболеваний легких // Первый Всероссийский съезд врачей восстановительной медицины: материалы съезда, 27 февраля – 01 марта. Москва, 2007. 282 с. EDN: QBOLBV

[57] Evans M, Lewis ED, Zakaria N, et al. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825–834. EDN: XMDCGF doi: 10.1111/jocd.13676

[58] Evans M., Lewis E.D., Zakaria N., et al. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity // J Cosmet Dermatol. 2021. Vol. 20, N 3. P. 825–834. EDN: XMDCGF doi: 10.1111/jocd.13676

[59] Draelos ZD, Diaz I. The benefits of a multimechanistic antiaging skin technology. Dermatol Ther (Heidelb). 2023;13(12):3111–3119. EDN: KFPAXA doi: 10.1007/s13555-023-01055-2

[60] Draelos Z.D., Diaz I. The benefits of a multimechanistic antiaging skin technology // Dermatol Ther (Heidelb). 2023. Vol. 13, N 12. P. 3111–3119. EDN: KFPAXA doi: 10.1007/s13555-023-01055-2

[61] Rattanawiwatpong P, Wanitphakdeedecha R, Bumrungpert A, et al. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. J Cosmet Dermatol. 2020;19(3):671–676. doi: 10.1111/jocd.13305

[62] Rattanawiwatpong P., Wanitphakdeedecha R., Bumrungpert A., et al. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial // J Cosmet Dermatol. 2020. Vol. 19, N 3. P. 671–676. doi: 10.1111/jocd.13305

[63] Zakirova GS, Gubanova EI, Gladko VV, et al. A randomized study of the safety and effectiveness of products based on stabilized hyaluronic acid for the correction of involutional changes in face and neck. Russ J Skin Venereal Dis = Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2018;21(1):53–60. EDN: XTCGRF doi: 10.18821/1560-9588-2018-21-1-51-53-60

[64] Закирова Г.Ш., Губанова Е.И., Гладько В.В., и др. Рандомизированное исследование безопасности и эффективности препаратов на основе стабилизированной гиалуроновой кислоты для коррекции инволюционных изменений кожи лица и шеи // Российский журнал кожных и венерических болезней. 2018. Т. 21, № 1. С. 53–60. EDN: XTCGRF doi: 10.18821/1560-9588-2018-21-1-51-53-60

[65] Gfrerer L, Kilmer SL, Waibel JS, et al. Dermal micro-coring for the treatment of moderate to severe facial wrinkles. Plast Reconstr Surg Glob Open. 2022;10(10):e4547. EDN: GHHPIH doi: 10.1097/GOX.0000000000004547

[66] Gfrerer L., Kilmer S.L., Waibel J.S., et al. Dermal micro-coring for the treatment of moderate to severe facial wrinkles // Plast Reconstr Surg Glob Open. 2022. Vol. 10, N 10. P. e4547. EDN: GHHPIH doi: 10.1097/GOX.0000000000004547

[67] Al-Otaibi HM, Al-Furayh NA, Al-Nooh BM, et al. Quality of life assessment among patients suffering from different dermatological diseases. Saudi Med J. 2021;42(11):1195–1200. EDN: BRBNEF doi: 10.15537/smj.2021.42.11.20210560

[68] Al-Otaibi H.M., Al-Furayh N.A., Al-Nooh B.M., et al. Quality of life assessment among patients suffering from different dermatological diseases // Saudi Med J. 2021. Vol. 42, N 11. P. 1195–1200. EDN: BRBNEF doi: 10.15537/smj.2021.42.11.20210560

[69] Băbțan AM, Vesa ȘC, Boșca BA, et al. High-frequency ultrasound assessment of skin and oral mucosa in metabolic syndrome patients: A cross-sectional study. J Clin Med. 2021;10(19):4461. EDN: PYETTI doi: 10.3390/jcm10194461

[70] Băbțan A.M., Vesa Ș.C., Boșca B.A., et al. High-frequency ultrasound assessment of skin and oral mucosa in metabolic syndrome patients: A cross-sectional study // J Clin Med. 2021. Vol. 10, N 19. P. 4461. EDN: PYETTI doi: 10.3390/jcm10194461

[71] Ruiz-Esparza GU, Flores-Arredondo JH, Segura-Ibarra V, et al. The physiology of cardiovascular disease and innovative liposomal platforms for therapy. Int J Nanomedicine. 2013;8:629–640. doi: 10.2147/IJN.S30599

[72] Ruiz-Esparza G.U., Flores-Arredondo J.H., Segura-Ibarra V., et al. The physiology of cardiovascular disease and innovative liposomal platforms for therapy // Int J Nanomedicine. 2013. Vol. 8. P. 629–640. doi: 10.2147/IJN.S30599

[73] Papaccio F, D’Arino A, Caputo S, et al. Focus on the contribution of oxidative stress in skin aging. Antioxidants (Basel). 2022;11(6):1121. EDN: LPMXBD doi: 10.3390/antiox11061121

[74] Papaccio F., D’Arino A., Caputo S., et al. Focus on the contribution of oxidative stress in skin aging // Antioxidants (Basel). 2022. Vol. 11, N 6. P. 1121. EDN: LPMXBD doi: 10.3390/antiox11061121

[75] Gill V, Kumar V, Singh K, et al. Advanced glycation end products (AGEs) may be a striking link between modern diet and health. Biomolecules. 2019;9(12):888. doi: 10.3390/biom9120888

[76] Gill V., Kumar V., Singh K., et al. Advanced glycation end products (AGEs) may be a striking link between modern diet and health // Biomolecules. 2019. Vol. 9, N 12. P. 888. doi: 10.3390/biom9120888

[77] Băbţan AM, Boşca BA, Petrescu NB, et al. Accumulation of N-epsilon carboxymethyl lysine in various tissues and organs related to diet-induced aging process. State of the art and experimental animal study. Human Veterinary Medicine. 2019;11(3):106–115.

[78] Băbţan A.M., Boşca B.A., Petrescu N.B., et al. Accumulation of N-epsilon carboxymethyl lysine in various tissues and organs related to diet-induced aging process. State of the art and experimental animal study // Human Veterinary Medicine. 2019. Vol. 11, N 3. P. 106–115.

[79] Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis. 2020;11(6):444. EDN: VKPPTY doi: 10.1038/s41419-020-2649-z

[80] Sreedhar A., Aguilera-Aguirre L., Singh K.K. Mitochondria in skin health, aging, and disease // Cell Death Dis. 2020. Vol. 11, N 6. P. 444. EDN: VKPPTY doi: 10.1038/s41419-020-2649-z

[81] Prahl S, Kueper T, Biernoth T, et al. Aging skin is functionally anaerobic: Importance of coenzyme Q10 for antiaging skin care. Biofactors. 2008;32(1-4):245–255. doi: 10.1002/biof.5520320129

[82] Prahl S., Kueper T., Biernoth T., et al. Aging skin is functionally anaerobic: Importance of coenzyme Q10 for antiaging skin care // Biofactors. 2008. Vol. 32, N 1-4. P. 245–255. doi: 10.1002/biof.5520320129

[83] Bowman A, Birch-Machin MA. Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts. J Invest Dermatol. 2016;136(5):912–919. doi: 10.1016/j.jid.2016.01.017

[84] Bowman A., Birch-Machin M.A. Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts // J Invest Dermatol. 2016. Vol. 136, N 5. P. 912–919. doi: 10.1016/j.jid.2016.01.017

[85] Passos JF, Zglinicki T. Mitochondrial dysfunction and cell senescence-skin deep into mammalian aging. Aging (Albany NY). 2012;4(2):74–75. doi: 10.18632/aging.100432

[86] Passos J.F., Zglinicki T. Mitochondrial dysfunction and cell senescence-skin deep into mammalian aging // Aging (Albany NY). 2012. Vol. 4, N 2. P. 74–75. doi: 10.18632/aging.100432

[87] Feichtinger RG, Sperl W, Bauer JW, et al. Mitochondrial dysfunction: A neglected component of skin diseases. Exp Dermatol. 2014;23(9):607–614. doi: 10.1111/exd.12484

[88] Feichtinger R.G., Sperl W., Bauer J.W., et al. Mitochondrial dysfunction: A neglected component of skin diseases // Exp Dermatol. 2014. Vol. 23, N 9. P. 607–614. doi: 10.1111/exd.12484

[89] Hussain M, Krishnamurthy S, Patel J, et al. Skin abnormalities in disorders with DNA repair defects, premature aging, and mitochondrial dysfunction. J Invest Dermatol. 2021;141(4S):968–975. EDN: STJNLK doi: 10.1016/j.jid.2020.10.019

[90] Hussain M., Krishnamurthy S., Patel J., et al. Skin abnormalities in disorders with dna repair defects, premature aging, and mitochondrial dysfunction // J Invest Dermatol. 2021. Vol. 141, N 4S. P. 968–975. EDN: STJNLK doi: 10.1016/j.jid.2020.10.019

[91] Wang Z, Wang Y, Bradbury N, et al. Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes. Sci Rep. 2020;10(1):21732. EDN: UYCSIV doi: 10.1038/s41598-020-78244-y

[92] Wang Z., Wang Y., Bradbury N., et al. Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes // Sci Rep. 2020. Vol. 10, N 1. P. 21732. EDN: UYCSIV doi: 10.1038/s41598-020-78244-y

[93] Imaeva NA, Potekaev NN, Tkachenko SB, Shuginina EA. Microcirculation disturbances in various skin ageing types. Cardiovascular Therapy Prevention. 2008;7(3):107–110. EDN: IJULDX

[94] Имаева Н.А., Потекаев Н.Н., Ткаченко С.Б., Шугинина Е.А. Особенности нарушения микроциркуляции при различных типах старения кожи // Кардиоваскулярная терапия и профилактика. 2008. Т. 7, № 3. С. 107–110. EDN: IJULDX

[95] Bentov I, Reed MJ. The effect of aging on the cutaneous microvasculature. Microvasc Res. 2015;100:25–31 doi: 10.1016/j.mvr.2015.04.004

[96] Bentov I., Reed M.J. The effect of aging on the cutaneous microvasculature // Microvasc Res. 2015. Vol. 100. P. 25–31. doi: 10.1016/j.mvr.2015.04.004

[97] Feher A, Broskova Z, Bagi Z. Age-related impairment of conducted dilation in human coronary arterioles. Am J Physiol Heart Circ Physiol. 2014;306(12):H1595–1601. doi: 10.1152/ajpheart.00179.2014

[98] Feher A., Broskova Z., Bagi Z. Age-related impairment of conducted dilation in human coronary arterioles // Am J Physiol Heart Circ Physiol. 2014. Vol. 306, N 12. P. H1595–1601. doi: 10.1152/ajpheart.00179.2014

[99] Efimov AA, Savenkova EN, Alekseev YD. Analysis of synchronism age changes of elastic properties of big arteries and human skin. Sovremennye problemy nauki i obrazovaniya. 2013;(3):125. EDN: RPOKFX

[100] Ефимов А.А., Савенкова Е.Н., Алексеев Ю.Д. Анализ синхронности возрастных изменений эластических свойств крупных артерий и кожи человека // Современные проблемы науки и образования. 2013. № 3. С. 125. EDN: RPOKFX

[101] Kulchitskaya DB, Fesyun AD, Yusova ZY, et al. Endothelium functional activity in different morphotypes of facial skin aging. Russ J Clin Dermatol Venereol. 2022;21(2):238–241. EDN: SOQXTB doi: 10.17116/klinderma202221021238

[102] Кульчицкая Д.Б., Фесюн А.Д., Юсова Ж.Ю., и др. Особенности функциональной активности эндотелия при различных морфотипах старения кожи лица // Клиническая дерматология и венерология. 2022. Т. 21, № 2. С. 238–241. EDN: SOQXTB doi: 10.17116/klinderma202221021238

[103] Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253–258. doi: 10.4161/derm.21923

[104] Papakonstantinou E., Roth M., Karakiulakis G. Hyaluronic acid: A key molecule in skin aging // Dermatoendocrinol. 2012. Vol. 4, N 3. P. 253–258. doi: 10.4161/derm.21923

[105] Vasvani S, Kulkarni P, Rawtani D. Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies. Int J Biol Macromol. 2020;151:1012–1029. EDN: PZBGFS doi: 10.1016/j.ijbiomac.2019.11.066

[106] Vasvani S., Kulkarni P., Rawtani D. Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies // Int J Biol Macromol. 2020. Vol. 151. P. 1012–1029. EDN: PZBGFS doi: 10.1016/j.ijbiomac.2019.11.066

[107] Bravo B, Correia P, Gonçalves JE, et al. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol Ther. 2022;35(12):e15903. EDN: HFVRIH doi: 10.1111/dth.15903

[108] Bravo B., Correia P., Gonçalves J.E., et al. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence // Dermatol Ther. 2022. Vol. 35, N 12. P. e15903. EDN: HFVRIH doi: 10.1111/dth.15903

[109] Konchugova TV. Laser phoresis ― development prospects of the method (brief literature report). Vestnik novyh medicinskih tehnologii. 2016;(3): 289–295. EDN: WLSLON

[110] Кончугова Т.В. Лазерофорез ― перспективы развития метода (краткий обзор литературы) // Вестник новых медицинских технологий. Электронное издание. 2016. № 3. С. 289–295. EDN: WLSLON

[111] Uiba VV, Kotenko V, Korchazhkina NB, Babyakin AF. Natural and preformed physical factors in resort treatment of arthrosis of large joints. Training manual. Vol. 1. Pyatigorsk; 2011. 20 р. (In Russ.) EDN: PXDXGT.

[112] Уйба В.В., Котенко К.В., Корчажкина Н.Б., Бабякин А.Ф. Природные и преформированные физические факторы в курортном лечении артроза крупных суставов. Учебное пособие. Т. 1. Пятигорск, 2011. 20 с. EDN: PXDXGT

[113] Moskvin SV. Efficiency of laser therapy. Vol. 2. Moscow-Tver: Triada; 2014. 896 р. (In Russ.)

[114] Москвин С.В. Эффективность лазерной терапии. Т. 2. Москва-Тверь: Триада, 2014. 896 с. (Серия: Эффективная лазерная терапия).

[115] Ulashchik VS. Combined physical therapy: General information, interaction between physical factors. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kultury = Problems Balneol Physiother Exercise Ther. 2016;(6):4–11. EDN: XHUGKX doi: 10.17116/kurort201664-11

[116] Улащик В.С. Сочетанная физиотерапия: общие сведения, взаимодействие физических факторов // Вопросы курортологии, физиотерапии и лечебной физической культуры. 2016. № 6. С. 4–11. EDN: XHUGKX doi: 10.17116/kurort201664-11

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