Whole body vibration technique in rehabilitation of children with cystic fibrosis

Abstract

BACKGROUND: Cystic fibrosis (or mucoviscidosis) is a severe genetic disease, which leads to disability and requires a permanent rehabilitation treatment aimed at improving the pulmonary function lung and the effort tolerance starting from childhood. The whole-body vibration (WBV) technique can potentially improve the effort tolerance and quality of life in patients with cystic fibrosis.

AIM: To evaluate the efficacy and safety of the WBV technique in improving the effort tolerance in patients with cystic fibrosis.

MATERIALS AND METHODS: Randomized controlled study enrolling 60 patients with pulmonary or mixed form of cystic fibrosis aged 8 to 17 years. Patients were randomized into three groups: the patients in the experimental Group 1 received a course of conventional kinesiotherapy combined with the WBV; in the experimental Group 2, the course of conventional kinesiotherapy combined with the WBV was enhanced with the aerobic exercises on an exercise bike; and the comparison group patients received only conventional kinesiotherapy. The study duration was consistent with the hospital stay time (12 days); the patients received a rehabilitation course of 10 exercises. The primary endpoint was the increased walking distance in the six-minute walk test. The methods of evaluation involved the pre-/post-treatment six-minute walk test results and the PedsQL 4.0 Generic Core Scales quality of life scores.

RESULTS: The comparative analysis results demonstrate the statistically significantly increased six-minute walk test distance in the experimental Groups 1 and 2, which evidences the efficacy of the WBV technique aimed at improving the effort tolerance in patients with cystic fibrosis. The group that received kinesiotherapy combined with the WBV and aerobic exercises showed a more pronounced effect. In the comparison group, the six-minute walk test results did not significantly change. Based on the study results, no statistically significant change of the quality of life occurred in any group.

CONCLUSION: Integrating the WBV into the individual rehabilitation programs for patients with cystic fibrosis can improve the effort tolerance. This technique can be used both combined with the aerobic exercises, and as an alternative training method, if a patient cannot perform aerobic exercises due to the severity of his or her condition or for epidemiological indications.

Keywords

cystic fibrosis / kinesiotherapy / whole-body vibration / effort tolerance / six-minute walk test

References

[1] Kashirskaya NY, Kapranov NI, Kondratieva EI. Cystic fibrosis. Moscow: Medpraktika-M; 2021. 680 р. (In Russ.)

[2] Каширская Н.Ю., Капранов Н.И., Кондратьева Е.И. Муковисцидоз. Москва: Медпрактика-М, 2021. 680 с.

[3] Register of patients with cystic fibrosis in the Russian Federation. 2020. Ed by E.I. Kondratieva, S.A. Krasovsky, M.A. Starinova, et al. Moscow: Medpraktika-M; 2022. 68 р. (In Russ.)

[4] Регистр пациентов с муковисцидозом в Российской Федерации. 2020 / под ред. Е.И. Кондратьевой, С.А. Красовского, М.А. Стариновой, и др. Москва: Медпрактика-М, 2022. 68 с.

[5] Davis PB. Cystic fibrosis since 1938. Am J Respir Crit Care Med. 2006;173(5):475–482. doi: 10.1164/rccm.200505-840OE

[6] Davis P.B. Cystic fibrosis since 1938 // Am J Respir Crit Care Med. 2006. Vol. 173, N 5. P. 475–482. doi: 10.1164/rccm.200505-840OE

[7] Guo J, Garratt A, Hill A. Worldwide rates of diagnosis and effective treatment for cystic fibrosis. J Cyst Fibros. 2022;21(3):456–462. EDN: PWOXET doi: 10.1016/j.jcf.2022.01.009

[8] Guo J., Garratt A., Hill A. Worldwide rates of diagnosis and effective treatment for cystic fibrosis // J Cyst Fibros. 2022. Vol. 21, N 3. P. 456–462. EDN: PWOXET doi: 10.1016/j.jcf.2022.01.009

[9] Roth J, Wust M, Rawer R, et al. Whole body vibration in cystic fibrosis: A pilot study. J Musculoskelet Neuronal Interact. 2008;8(2):179–187.

[10] Roth J., Wust M., Rawer R., et al. Whole body vibration in cystic fibrosis: A pilot study // J Musculoskelet Neuronal Interact. 2008. Vol. 8, N 2. P. 179–187.

[11] Rietschel E, van Koningsbruggen S, Fricke O, et al. Whole body vibration: A new therapeutic approach to improve muscle function in cystic fibrosis? Int J Rehabil Res. 2008;31(3):253–256. doi: 10.1097/MRR.0b013e3282fb783d

[12] Rietschel E., van Koningsbruggen S., Fricke O., et al. Whole body vibration: A new therapeutic approach to improve muscle function in cystic fibrosis? // Int J Rehabil Res. 2008. Vol. 31, N 3. P. 253–256. doi: 10.1097/MRR.0b013e3282fb783d

[13] O’Keefe K, Orr R, Huang P, et al. The effect of whole body vibration exposure on muscle function in children with cystic fibrosis: A pilot efficacy trial. J Clin Med Res. 2013;5(3):205–216. doi: 10.4021/jocmr1137w

[14] O’Keefe K., Orr R., Huang P., et al. The effect of whole body vibration exposure on muscle function in children with cystic fibrosis: A pilot efficacy trial // J Clin Med Res. 2013. Vol. 5, N 3. P. 205–216. doi: 10.4021/jocmr1137w

[15] Sitjà Rabert M, et al. Whole-body vibration training for patients with neurodegenerative disease. Cochrane Database Syst Rev. 2012;(2):CD009097. doi: 10.1002/14651858.cd009097.pub2

[16] Sitjà Rabert M., et al. Whole-body vibration training for patients with neurodegenerative disease // Cochrane Database Syst Rev. 2012. N 2. P. CD009097. doi: 10.1002/14651858.cd009097.pub2

[17] Hoveidaei AH, Hashemi SM, Pazoki S, et al. Effects of whole-body vibration on chronic ankle instability: A systematic review. Ann Med Surg. 2024;86(1):401–411. EDN: ACNQWM doi: 10.1097/ms9.0000000000001510

[18] Hoveidaei A.H., Hashemi S.M. Pazoki S., et al. Effects of whole-body vibration on chronic ankle instability: A systematic review // Ann Med Surg. 2024. Vol. 86, N 1. P. 401–411. EDN: ACNQWM doi: 10.1097/ms9.0000000000001510

[19] Herrero AJ, Menéndez H, Gil L, et al. Effects of whole-body vibration on blood flow and neuromuscular activity in spinal cord injury. Spinal Cord. 2011;49(4):554–559. doi: 10.1038/sc.2010.151

[20] Herrero A.J., Menéndez H., Gil L., et al. Effects of whole-body vibration on blood flow and neuromuscular activity in spinal cord injury // Spinal Cord. 2011. Vol. 49, N 4. P. 554–559. doi: 10.1038/sc.2010.151

[21] Zhou J, Pang L, Chen N, et al. Whole-body vibration training —better care for COPD patients: A systematic review and meta-analysis. Int J COPD. 2018;13:3243–3254. doi: 10.2147/COPD.S176229

[22] Zhou J., Pang L., Chen N., et al. Whole-body vibration training — better care for COPD patients: A systematic review and meta-analysis // Int J COPD. 2018. Vol. 13. P. 3243–3254. doi: 10.2147/COPD.S176229

[23] Han YG, Kim MK. Effectiveness of whole-body vibration in patients with cerebral palsy: A systematic review and meta-analysis. Medicine (United States). 2023;102(48):e36441. EDN: PINNVS doi: 10.1097/MD.0000000000036441

[24] Han Y.G., Kim M.K. Effectiveness of whole-body vibration in patients with cerebral palsy: A systematic review and meta-analysis // Medicine (United States). 2023. Vol. 102, N 48. P. e36441. EDN: PINNVS doi: 10.1097/MD.0000000000036441

[25] Graham BL, Steenbruggen I, Miller MR, et al. Standardization of spirometry 2019 update an official American Thoracic Society and European Respiratory Society technical statement. Am J Respir Crit Care Med. 2019;200(8):e70–e88. doi: 10.1164/rccm.201908-1590ST

[26] Graham B.L., Steenbruggen I., Miller M.R., et al. Standardization of spirometry 2019 update an official American Thoracic Society and European Respiratory Society technical statement // Am J Respir Crit Care Med. 2019. Vol. 200, N 8. P. e70–e88. doi: 10.1164/rccm.201908-1590ST

[27] Ziegler B, Rovedder PM, Oliveira CL, et al. Predictors of oxygen desaturation during the six-minute walk test in patients with cystic fibrosis. J Bras Pneumol. 2009;35(10):957–965. doi: 10.1590/s1806-37132009001000003

[28] Ziegler B., Rovedder P.M., Oliveira C.L., et al. Predictors of oxygen desaturation during the six-minute walk test in patients with cystic fibrosis // J Bras Pneumol. 2009. Vol. 35, N 10. P. 957–965. doi: 10.1590/s1806-37132009001000003

[29] Mikhailova AA, Korchazhkina NB, Kotenko KV, Koneva ES. Experience in the application of robotic biomechanical medical rehabilitation techniques in patients after acute cerebral circulatory failure. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kultury = Problems of balneology, physiotherapy and exercise therapy. 2021;98(3-2):127–128. (In Russ.) EDN: OOEAJW doi: 10.17116/kurort20219803221

[30] Михайлова А.А., Корчажкина Н.Б., Котенко К.В., Конева Е.С. Опыт применения методик роботизированной биомеханической медицинской реабилитации у пациентов после острого нарушения мозгового кровообращения // Вопросы курортологии, физиотерапии и лечебной физической культуры. 2021. Т. 98, № 3-2. С. 127–128. EDN: OOEAJW doi: 10.17116/kurort20219803221

[31] Mikhailova AA, Korchazhkina NB, Koneva ES, Kotenko KV. Psychocorrective effect of application of combined medical rehabilitation methods in patients with ischemic stroke. Russ J Physical Therapy, Balneotherapy Rehab. 2020;19(6):380–383. EDN: UBARKW doi: 10.17816/1681-3456-2020-19-6-5

[32] Михайлова А.А., Корчажкина Н.Б., Конева Е.С., Котенко К.В. Психокорригирующий эффект применения сочетанных методик медицинской реабилитации у пациентов, перенесших ишемический инсульт // Физиотерапия, бальнеология и реабилитация. 2020. Т. 19, № 6. С. 380–383. EDN: UBARKW doi: 10.17816/1681-3456-2020-19-6-5

[33] Wilson LM, Morrison L, Robinson KA. Airway clearance techniques for cystic fibrosis: An overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2019;2019(1): CD011231. doi: 10.1002/14651858.CD011231.pub2

[34] Wilson L.M., Morrison L., Robinson K.A. Airway clearance techniques for cystic fibrosis: An overview of Cochrane systematic reviews // Cochrane Database Syst Rev. 2019. Vol. 2019, N 1. P. CD011231. doi: 10.1002/14651858.CD011231.pub2

[35] Hebestreit H, Hulzebos EH, Schneiderman JE, et al. Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis. Am J Respir Crit Care Med. 2019;199(8):987–995. doi: 10.1164/rccm.201806-1110OC

[36] Hebestreit H., Hulzebos E.H., Schneiderman J.E., et al. Cardiopulmonary exercise testing provides additional prognostic information in cystic fibrosis // Am J Respir Crit Care Med. 2019. Vol. 199, N 8. P. 987–995. doi: 10.1164/rccm.201806-1110OC

[37] Hebestreit H, Schmid K, Kieser S, et al. Quality of life is associated with physical activity and fitness in cystic fibrosis. BMC Pulm Med. 2014;14:26. doi: 10.1186/1471-2466-14-26

[38] Hebestreit H., Schmid K., Kieser S., et al. Quality of life is associated with physical activity and fitness in cystic fibrosis // BMC Pulm Med. 2014. Vol. 14. P. 26. doi: 10.1186/1471-2466-14-26

[39] Roshanzamir Z, Shirzadi R, Modaresi M. The correlation between 6-min walk test and respiratory parameters in children with cystic fibrosis. Ir J Med Sci. 2022;191(1):289–294. EDN: SXGKMI doi: 10.1007/s11845-021-02564-9

[40] Roshanzamir Z., Shirzadi R., Modaresi M. The correlation between 6-min walk test and respiratory parameters in children with cystic fibrosis // Ir J Med Sci. 2022. Vol. 191, N 1. P. 289–294. EDN: SXGKMI doi: 10.1007/s11845-021-02564-9

[41] Rehn B, Lidström J, Skoglund J, Lindström B. Effects on leg muscular performance from whole-body vibration exercise: A systematic review. Scand J Med Sci Sports. 2007;17(1):2–11. doi: 10.1111/j.1600-0838.2006.00578.x

[42] Rehn B., Lidström J., Skoglund J., Lindström B. Effects on leg muscular performance from whole-body vibration exercise: A systematic review // Scand J Med Sci Sports. 2007. Vol. 17, N 1. P. 2–11. doi: 10.1111/j.1600-0838.2006.00578.x

[43] Middleton A, Christodoulou J, Munns C, Selvadurai HC. Whole body vibration training for children with cystic fibrosis. J Cystic Fibrosis. 2012;11:105. doi: 10.1016/s1569-1993(12)60362-2

[44] Middleton A., Christodoulou J., Munns C., Selvadurai H.C. Whole body vibration training for children with cystic fibrosis // J Cystic Fibrosis. 2012. Vol. 11. P. 105. doi: 10.1016/s1569-1993(12)60362-2

[45] Korchazhkina NB, Mikhailova AA. Features of the use of stable platforms with biological feedback in various socially significant diseases. Russ J Physical Therapy, Balneotherapy Rehab. 2019;18(2):103–106. EDN: KXDZOQ doi: 10.17816/1681-3456-2019-18-2-103-106

[46] Корчажкина Н.Б., Михайлова А.А. Особенности применения стабилоплатформ с биологической обратной связью при различных социально значимых заболеваниях // Физиотерапия, бальнеология и реабилитация. 2019. Т. 18, № 2. С. 103–106. EDN: KXDZOQ doi: 10.17816/1681-3456-2019-18-2-103-106

[47] Kotenko KV, Khan MA, Korchazhkina NB, et al. Modern non-medication technologies for medical rehabilitation of children. Moscow: GEOTAR-Media; 2022. 440 р. (In Russ.) EDN: IBGAKQ doi: 10.33029/9704-7062-6-MTM-2022-1-440

[48] Котенко К.В., Хан М.А., Корчажкина Н.Б., и др. Современные немедикаментозные технологии медицинской реабилитации детей. Москва: ГЭОТАР-Медиа, 2022. 440 с. EDN: IBGAKQ doi: 10.33029/9704-7062-6-MTM-2022-1-440

RIGHTS & PERMISSIONS

Eco-Vector