Quality of life of the patients with chronic prostatitis under the influence of complex balneopeloid and enzyme therapy with Longidase

Abstract

BACKGROUND: In modern medicine, among the main indicators of the effectiveness of therapeutic measures, the quality of life of the patient is singled out, which allows determining the degree of recovery of physical and mental health after treatment of acute conditions.

AIM: to evaluate the effectiveness of complex balneopeloid and enzyme therapy with longidase according to the monitoring of the quality of life of the patients suffering from chronic bacterial prostatitis.

MATERIALS AND METHODS: There have been observed 54 patients with chronic prostatitis. They were divided into 2 groups by simple randomization: in the comparison group (n=26) the patients were prescribed exercise therapy, internal and external administration of mineral water of Zheleznovodsk type, peloidotherapy with silt sulfide mud topically, antibiotic therapy with ceftriaxone, phytomicroclysters; in the main group (n=28), the patients additionally underwent antibiotic and enzyme therapy by peripheral indirect lymphotropic therapy. The efficiency was assessed using validated Quality of Life questionnaires: Chronic Prostatitis Symptom Scale (NIH-CPS) and SF-36 General Health Questionnaire (Social Functioning-36).

RESULTS: The analysis of the clinical effect of the new treatment technology revealed its advantage over the standardized therapy, which is proven by the monitoring of QoL indicators for 1 year after the spa treatment: recovery of QoL in the main group immediately after the treatment occurred by 59.7% (p <0.01), 6 months later ― by 72.7% (p <0.01), with a slight decrease in the rate in 12 months ― by 64.9% (p <0.01). The dynamics of physical and mental health indicators on the SF-36 scale was also observed with the same degree of confidence: compared with the baseline, the average improvement was 25.5% (p <0.01), 33.6% (p <0.01) and 27.3% (p <0.01) respectively. In the comparison group, the dynamics of indicators for all NIH-CPSI and SF-36 scales was also significant, but lower than similar indicators in the main group by 23–25% on average (p <0.01) and 12–15%, respectively.

CONCLUSION: The results of the study indicate the high effectiveness of complex balneopeloid and lymphotropic therapy with the patients suffering from chronic prostatitis at the stage of spa treatment.

Keywords

chronic prostatitis / spa treatment / Longidase / lymphotropic therapy / quality of life

References

[1] Brizhatyuk EV, Shevchenko SY. Influence of the lifestyle of a patient with chronic prostatitis on its quality. Urology Herald. 2020;8(3):13–17. (In Russ). doi: 10.21886/2308-6424-2020-8-3-13-17

[2] Брижатюк Е.В., Шевченко С.Ю. Влияние образа жизни больного хроническим простатитом на ее качество // Вестник урологии. 2020. Т. 8, № 3. С. 13–17. doi: 10.21886/2308-6424-2020-8-3-13-17

[3] Russian clinical recommendations. Urology. Ed. by Yu.G. Alyaeva, P.V. Glybochko, D.Yu. Pushkar. Moscow: GEOTAR-Media; 2016. 480 р. (In Russ).

[4] Российские клинические рекомендации. Урология / под ред. Ю.Г. Аляева, П.В. Глыбочко, Д.Ю. Пушкаря. Москва: ГЭОТАР-Медиа, 2016. 480 с.

[5] Tyuzikov IA, Grekov EA. Chronic prostatitis/chronic pelvic pain: Modern trends and prospects for treatment from the standpoint of evidence-based medicine. Experimental clin urology. 2022;(1):24–29. (In Russ). doi: 10.29188/2222-8543-2022-15-1-90-100

[6] Тюзиков И.А., Греков Е.А. Хронический простатит/синдром хронической тазовой боли: современные тренды и перспективы лечения с позиций доказательной медицины // Экспериментальная и клиническая урология. 2022. № 1. С. 24–29. doi: 10.29188/2222-8543-2022-15-1-90-100

[7] Magri VM, Boltri CT, Colombo R, et al. Multidisciplinary approach to prostatitis. Arch Ital Urol Androl. 2019;90(4):227–248. doi: 10.4081/aiua.2018.4.227

[8] Magri V.M., Boltri C.T., Colombo R., et al. Multidisciplinary approach to prostatitis // Arch Ital Urol Androl. 2019. Vol. 90, N 4. P. 227–248. doi: 10.4081/aiua.2018.4.227

[9] Pushkar DI, Gvozdev MI, Tupikina NV. Questionnaires as a tool for assessing the quality of life in urogynecological patients. Russ Bulletin Obstetrician-Gynecologist. 2013;13(1):23-29. (In Russ).

[10] Пушкарь Д.Ю., Гвоздев М.Ю., Тупикина Н.В. Вопросники как инструмент оценки качества жизни пациентки урогинекологического профиля // Российский вестник акушера-гинеколога. 2013. Т. 13, № 1. С. 23–29.

[11] Mkrtchyan AM, Kaisinova AS, Kocharian GV. Balneoploid and lymphotropic therapy in medical rehabilitation of patients with chronic prostatitis. Resort Med. 2015;(1):70–75. (In Russ).

[12] Мкртчян А.М., Кайсинова А.С., Кочарян Г.В. Бальнеопелоидо- и лимфотропная терапия в медицинской реабилитации больных хроническим простатитом // Курортная медицина. 2015. № 1. С. 70–75.

[13] Sanatorium-resort treatment: National Guide. Ed. by A.N. Razumov, V.I. Starodubov, G.N. Ponomarenko. Moscow: GEOTAR-Media; 2021. 752 р. (In Russ).

[14] Санаторно-курортное лечение: национальное руководство / под ред. А.Н. Разумова, В.И. Стародубова, Г.Н. Пономаренко. Москва: ГЭОТАР-Медиа, 2021. 752 с.

[15] Starokozhko LE, Chebotarev VV, Krasheninnikov VL, Gaidamak II. Assessment of the effectiveness of rectal candles on a hydrophilic basis for chronic bacterial prostatitis. Med News North Caucasus. 2012;25(1):70–72. (In Russ).

[16] Старокожко Л.Е., Чеботарев В.В., Крашенинников В.Л., Гайдамака И.И. Оценка эффективности ректальных свечей на гидрофильной основе при хроническом бактериальном простатите // Медицинский вестник Северного Кавказа. 2012. Т. 25, № 1. С. 70–72.

[17] Ter-Akopov GN, Efimenko NV, Glukhov AN, Kaisinova AS. On the development of programs and new medical technologies for sanatorium-resort treatment and medical rehabilitation in the Federal State Budgetary Institution of the SKFNCS FBBA of Russia. Resort Med. 2022;(1):5–15. doi: 10.51871/2304-0343_2022_1_5

[18] Тер-Акопов Г.Н., Ефименко Н.В., Глухов А.Н., Кайсинова А.С. О разработке программ и новых медицинских технологий санаторно-курортного лечения и медицинской реабилитации в ФГБУ СКФНКЦ ФМБА России // Курортная медицина. 2022. № 1. С. 5–15. doi: 10.51871/2304-0343_2022_1_5

[19] Talberg PI, Mazina SE, Andryukhin MI. Complex therapy of chronic prostatitis. Modern Problems Sci Education. 2015;(4):415. (In Russ).

[20] Тальберг П.И., Мазина С.Е., Андрюхин М.И. Комплексная терапия хронического простатита // Современные проблемы науки и образования. 2015. № 4. С. 415.

[21] Vinnik YY, Kuzmenko AV, Giaurgiev TA. Treatment of chronic prostatitis: Current state of the problem. Urology. 2021;(4):138–144. (In Russ). doi: 10.18565/urology.2021.4.138-144

[22] Винник Ю.Ю., Кузьменко А.В., Гяургиев Т.А. Лечение хронического простатита: современное состояние проблемы // Урология. 2021. № 4. С. 138–144. doi: 10.18565/urology.2021.4.138-144

[23] Kurortology of the Caucasian mineral waters. Vol. 1. Ed. by V.V. Uyba. Pyatigorsk: Publishing House; 2010. Р. 146–195. (In Russ).

[24] Курортология Кавказских Минеральных Вод / под общей ред. В.В. Уйба. Т. 1. Пятигорск: Издательский Дом, 2010. С. 146–195.

[25] Semkin VA, Nadtochny AG, Vozgoment OV, Ivanova AA. Limfatic therapy and its significance in the complex treatment of patients. Dentistry. 2020;99(5):116–121. (In Russ). doi: 10.17116/stomat202099051116

[26] Семкин В.А., Надточий А.Г., Возгомент О.В., Иванова А.А. Лимфатическая терапия и ее значение в комплексном лечении больных // Стоматология. 2020. Т. 99, № 5. P. 116–121. doi: 10.17116/stomat202099051116

[27] Avdoshin VP, Andryukhin MI, Mikhailikov TG, Pulbere SA. The experience of using the drug Longidase in the complex therapy of chronic prostatitis. Health and education in the 21st century. 2006;8(1):16. (In Russ).

[28] Авдошин В.П., Андрюхин М.И., Михайликов Т.Г., Пульбере С.А. Опыт применения препарата Лонгидаза в комплексной терапии хронического простатита // Здоровье и образование в XXI веке. 2006. Т. 8, № 1. С. 16.

[29] Zaitsev AV, Khodyreva LA, Dudareva AA, Pushkar DY. A modern view of the use of enzyme preparations in patients with chronic prostatitis. Clin Dermatol Venereol. 2016;15(3):53–60. (In Russ). doi: 10.17116/klinderma201615353-60

[30] Зайцев А.В., Ходырева Л.А., Дударева А.А., Пушкарь Д.Ю. Современный взгляд на применение ферментных препаратов у больных хроническим простатитом // Клиническая дерматология и венерология. 2016. Т. 15, № 3. С. 53–60. doi: 10.17116/klinderma201615353-60

[31] Kulchavenya EV, Shvetsova OP, Breusov AA. Justification of the appointment and effectiveness of the drug Longidase in patients with chronic prostatitis. Urology. 2018;(4):64–71. (In Russ). doi: 10.18565/urology.2018.4:64-71

[32] Кульчавеня Е.В., Швецова О.П., Бреусов А.А. Обоснование назначения и эффективность препарата Лонгидаза у больных хроническим простатитом // Урология. 2018. № 4. С. 64–71. doi: 10.18565/urology.2018.4:64-71

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