Photodynamic therapy for correction of involutive facial skin changes

Abstract

Background. The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy.

Objective: the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure.

Methods. The study involved patients aged 40−60 years with signs of involutive changes in the skin of the face. In group 1 (n = 36), patients underwent therapy using only light coherent radiation. In group 2 (n = 35), patients underwent PDT using light coherent radiation.

Results. According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group 2, more positive indicators were obtained than in group 1. When assessing safety, the results in groups 1 and 2 are comparable.

Conclusions. The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.

Keywords

photodynamic therapy / phototherapy / photoaging / involution / chlorin E6 / photosensitizer

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[12] Патент РФ на изобретение RU № 2523380 C1. Пономарёв Г.В., Койфман О.И., Шестаков В.Н. Фотосенсибилизатор и способ его получения. Доступно по: https://yandex.ru/patents/doc/RU2523380C1_20140720. Ссылка активна на 15.05.2020.

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