Cytogenetic investigation of peripheral blood lymphocytes in Hodgkin's lymphomas

S N Kolubaeva; A V Novitsky; L V Myakoshina; N V Illyin; J N Vinogradova; V L Evtushenko; N A Viktorova; O P Krasnova; A A Titova

doi:10.17816/MAJ9347-51

Medical academic journal ›› 2009, Vol. 9 ›› Issue (3) : 47 -51. DOI: 10.17816/MAJ9347-51

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Cytogenetic investigation of peripheral blood lymphocytes in Hodgkin's lymphomas

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Abstract

Chromosomal injuries in 84 patients with Hodgkin's lymphoma were investigated by differential painting. Clonal aberrations were found in 22 patients and 61 patients had various nonclonal aberrations. Comparison of discovered injuries with the injuries published by others shows that the character of injuries and immunological status may depend on geographical regions where the patients live.The most frequent regions of chromosomal injuries were localized in the chromosomes 2.3,6,12, X.

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Hodgkin's lymphoma / chromosomal clonal and nonclonal injuries / stage of illness / peripheral blood lymphocytes

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S N Kolubaeva, A V Novitsky, L V Myakoshina, N V Illyin, J N Vinogradova, V L Evtushenko, N A Viktorova, O P Krasnova, A A Titova. Cytogenetic investigation of peripheral blood lymphocytes in Hodgkin's lymphomas. Medical academic journal, 2009, 9(3): 47-51 DOI:10.17816/MAJ9347-51

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[1]	Богданов А.Н., Саржевский В.О., Колюбаева С.Н. и др. Цитогенетическое исследование злокачественных лимфом // Вестник СПб университета. 2008. Серия 11. №3. С. 126-131.

[2]	Колюбаева С.Н., Саржевский В.О., Титова А.А. и др. Цитогенетическая характеристика больных с хроническим лимфоцитарным лейкозом // Мед. акад. журн. 2006. Т. 6. №3. С. 109-114.

[3]	Новик А.А. Классификация злокачественных лимфом. СПб.: Элби, 2000. 126 с.

[4]	Рябченко Н.И., Насонова В.А., Фесенко У.И. и др. Анализ хромосомных повреждений в лимфоцитах пациентов с лимфомой Ходжкина после химиотерапии и радиационной терапии // Радиац. биол. ра-диоэкол. 2008. Т. 48. № 2. С. 146-152.

[5]	An international system for human cytogenetic nomenclature / Ed. L.G. Shaffer, N. Tommerup. 2005. 130 p.

[6]	Brusa G., Zuffa E., Hattinger CM. et al. Genomic imbalances associated with secondary acute leukemias in Hodgkin lymphoma // Oncol. Rep. 2007. Vol. 18. № 6. P. 1427-1434.

[7]	Cady F.M., O'Neil B.P., Law M.E. Del (6)(g22) and BCL6 rearrangement in primary CNS lymphoma are indicators jf an aggressive clinical course // J. Clin. Oncol. 2008. Vol. 26. № 29. P. 4814-4819.

[8]	Harris N.L. The many faces of Hodgkin's disease around the world: What have we learned fromits pathology? //Ann. of Oncology. 1998. Vol. 5. P. 45-56.

[9]	Jaffe E.S., Harris N.L., Stein H, Vardiman J.W. Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. Lyon: IARCPress, 2001.

[10]	Rudiger Т., Jaffe E.S., Delsol G. et al. Workshop report on Hodgkin's disease and related diseases («grey zone» lymphoma) //Ann. of Oncology. 1998. Vol. 5. P. 31-38.