Psychopharmacological properties of peptides with nootropic type of action

Abstract

The phychopharmacological analysis of 9 peptide drugs (cortexin, cerebrolysine, deltaran, cortagen, oleyl-cortagen, semax, selank, noopept, dilept) in comparison with piracetam and mexidol was shown that cerebrolysine (1 mg/kg), oleyl-cortagen (1 mg/kg) and piracetam (200 mg/kg) possessed activating effect on motor and research components of behavior in "open field"test, and piracetam and cerebrolysine increased the emotional status of rats. Deprimating type of action was revealed in dilept (1 mg/kg), which decreased horizontal and vertical motor activity in rats. Only one peptide, selank (0,1 mg/kg), possessed antiaggresion action. A number of peptides (oleyl-cortagen, dilept and cortexin) demonstrated antidepressant effects, while cerebrolysine (1 mg/kg), oleyl-cortagen (1 mg/kg) and selank (0,1 mg/kg), on the other hand, performed depressant action on rat behavior in the Porsolt'test. At last, oleyl-cortagen and cortexin activated self-stimulation of the lateral hypothalamus. Therefore, the significant psychoactivating properties are typical for cerebrolysine, oleyl-cortagen, cortexin and piracetam, while dilept, selank and in the less degree semax inhibited rat behavior, demonstrating deprimating type of action.

Keywords

phychopharmacology / peptides / cortexin / cerebrolysine / deltaran / cortagen / oleyl-cortagen / semax / selank / noopept / dilept

RIGHTS & PERMISSIONS

Shabanov P.D., Lebedev A.A.