Current views about reperfusion injury mechanism in infusion therapy of shock and methods its prevention

Abstract

A review of the literature concerning the mechanism of the reperfusion injury in the infusion therapy of the haemorrhagic shock. On the bases of literature data and own investigations were shown that after restoration of circulation develops oxygen paradox, activates peroxidation, damages of cells membranes. The biochemical mechanism of the reperfusion injure was described. Antihypoxants, antioxidants, inhibitors of xanthineoxidase-catalyzed production of superoxide radical, inhibitors of nitric oxide synthesis are effective for treatment of the reperfusion injury in the infusion therapy of the haemorrhagic shock.

Keywords

haemorrhagic shock / infusion therapy / ischemia / reperfusion / antihypoxants / antioxidants / inhibitors of xanthine oxidase / inhibitors of nitric oxide

RIGHTS & PERMISSIONS

Remizova M.I.