Optimization of M2e cassette amino acid composition for the development of universal influenza vaccine

Daria А. Mezhenskaya; Irina N. Isakova-Sivak; Anastasiya E. Katelnikova; Larisa G. Rudenko

doi:10.17816/MAJ76326

Medical academic journal ›› 2021, Vol. 21 ›› Issue (3) : 127 -130. DOI: 10.17816/MAJ76326

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Optimization of M2e cassette amino acid composition for the development of universal influenza vaccine

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Abstract

The development of a universal influenza vaccine with a wide spectrum and duration of action is one of the serious public health problems. This study is dedicated to optimization of an immunogen covering the M2e epitopes of influenza A viruses circulating in the natural reservoir, as well as the creation of a prototype of a universal influenza vaccine with subsequent quantitative and qualitative assessment of the induced anti-M2e responses in ferrets.

Keywords

influenza virus / universal influenza vaccine / M2e epitopes / ferret model / ELISA

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Daria А. Mezhenskaya, Irina N. Isakova-Sivak, Anastasiya E. Katelnikova, Larisa G. Rudenko. Optimization of M2e cassette amino acid composition for the development of universal influenza vaccine. Medical academic journal, 2021, 21(3): 127-130 DOI:10.17816/MAJ76326

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