Analysis of metabolomic and genomic markers for diagnosing cardiovascular diseases

Abstract

Cardiovascular disease is the leading cause of death in the population. Unfortunately, cardiovascular disease and its associated risks are often difficult to diagnose due to the many factors associated with age and other comorbidities that lead to significant uncertainty in diagnostic classification and therapeutic decision making. Therefore, there is a great need to find new biomarkers for more accurate diagnosis, risk assessment and treatment recommendations for both acute and chronic cardiovascular disease. This article presents an analysis of metabolomic and genomic markers used for the diagnosis of cardiovascular disease. The study of the metabolome in combination with the genome and proteome can provide important information about both the pathogenesis of cardiovascular disease and the ability to search for and identify new cardiovascular disease biomarkers. Along with the fundamental data on new cardiovascular disease biomarkers, there is an urgent need for further research confirming their great potential for practical health care.

Keywords

metabolomic markers / genomic markers / cardiovascular diseases

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Zharkova Z.V., Yasenyavskaya A.L., Nikitina I.B., Goretova I.V., Fedoseev I.V., Bashkina O.А., Samotrueva M.A.