The degree of severity and structure of cognitive disorders in patients with cerebrovascular disease, depending on the level of 25-hydroxycalciferol

Abstract

BACKGROUND: In recent years, a significant increase in cerebrovascular pathology, which is often accompanied by cognitive deficits, has been noted all over the world.

AIM: The aim of this study is to determine the severity and structure of cognitive disorders depending on the level of 25(OH)D in patients with cerebrovascular disease.

MATERIALS AND METHODS: 146 patients with cerebrovascular disease aged from 30 to 80 years were examined. The comparison group consisted of 40 patients, comparable in age and gender, without the studied pathology. During the study, the level of 25(OH)D, interleukin-6, highly sensitive C-reactive protein in the peripheral blood was determined in patients and a neuropsychological examination was performed.

RESULTS: In patients with cerebrovascular disease, the level of 25(OH)D it was lower in comparison with patients without this pathology. Patients with higher rates of inflammatory factors had significantly lower concentrations of 25(OH)D in the peripheral blood. The study revealed a correlation between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing: direct — MMSE, MoCA, FAB and reverse — Schulte tables (performance). When assessing cognitive disorders in patients with cerebrovascular disease, according to the results of neuropsychological testing, it was possible to identify significantly significant differences between the main and the comparison group according to the following scales: MMSE (p = 0.04), MoCA (p = 0.001), FAB (p = 0.007), Schulte Tables (performance) (p = 0.06), respectively. When interpreting the MMSE scale, significantly significant differences between the groups were found in the attention assessment (p = 0.03), and in the analysis of the MoCA scale — in the sections delayed reproduction (p = 0.03) and conceptualization (p = 0.04), respectively. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure, which was observed in 53-76% of cases in our study.

CONCLUSIONS: The study found that the higher the concentration of 25(OH)D and the lower the level of interleukin-6 and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive disorders. In patients with cerebrovascular disease, memory is most affected by the type of delayed reproduction failure.

Keywords

cerebrovascular disease / 25-hydroxycalciferol / interleukin-6 / highly sensitive C-reactive protein / cognitive impairment

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