Main scientific achievements of the academician of the RAS Vladimir Kh. Khavinson: peptides and aging
Galina A. Ryzhak , Olga N. Mikhailova , Lyudmila S. Kozina , Irina G. Popovich , Alexander V. Arutyunyan
Medical academic journal ›› 2024, Vol. 24 ›› Issue (1) : 51 -58.
Main scientific achievements of the academician of the RAS Vladimir Kh. Khavinson: peptides and aging
The article is dedicated to the memory of the outstanding Russian gerontologist, director of the Saint Petersburg Institute of Bioregulation and Gerontology, academician of the Russian Academy of Sciences, professor Vladimir Kh. Khavinson.
peptide regulation / molecular modeling / clinical studies / organizational and international activities
| [1] |
Morozov VG, Khavinson VG. A new class of biological regulators of multicellular systems – cytomedins. Uspehi sovremennoy biologii. 1983;96(3–6):339–352. (In Russ.) EDN: ZEGSVP |
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Морозов В.Г., Хавинсон В.Х. Новый класс биологических регуляторов многоклеточных систем — цитомедины // Успехи современной биологии. 1983. Т. 96, № 3–6. С. 339–352. EDN: ZEGSVP |
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Khavinson VKh. Peptide medicines: past, present, future. Clinical medicine (Russian journal). 2020;98(3):165–177. EDN: NZRQRF doi: 10.30629/0023-2149-2020-98-3-165-177 |
| [4] |
Хавинсон В.Х. Лекарственные пептидные препараты: прошлое, настоящее, будущее // Клиническая медицина. 2020. T. 98, № 3. C. 165–177. EDN: NZRQRF doi: 10.30629/0023-2149-2020-98-3-165-177 |
| [5] |
Anisimov VN, Khavinson VKh, Morozov VG. Carcinogenesis and aging. IV. Effect of low-molecular weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Mech Aging Dev. 1982;19(3):245–258. doi: 10.1016/0047-6374(82)90057-4 |
| [6] |
Anisimov V.N., Khavinson V.Kh., Morozov V.G. Carcinogenesis and aging. IV. Effect of low-molecular weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice // Mech Aging Dev. 1982. Vol. 19, N 3. P. 245–258. doi: 10.1016/0047-6374(82)90057-4 |
| [7] |
Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139–149. EDN: MXKAHH doi: 10.1007/s10522-009-9249-8 |
| [8] |
Anisimov V.N., Khavinson V.Kh. Peptide bioregulation of aging: results and prospects // Biogerontology. 2010. Vol. 11, N 2. P. 139–149. EDN: MXKAHH doi: 10.1007/s10522-009-9249-8 |
| [9] |
Tutelian VA, Khavinson VKh, Malinin VV. Physiological role of short peptides in nutrition. Bull Exp Biol Med. 2003;135(1):1–5. EDN: YZCZLH doi: 10.1023/a:1023467622252 |
| [10] |
Тутельян В.А., Хавинсон В.Х., Малинин В.В. Физиологическая роль коротких пептидов в питании // Бюллетень экспериментальной биологии и медицины. 2003. T. 135, № 1. C. 1–5. EDN: YZCZLH doi: 10.1023/a:1023467622252 |
| [11] |
Khavinson VKh. Peptides and ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11–144. |
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Khavinson V.Kh. Peptides and ageing // Neuro Endocrinol Lett. 2002. Vol. 23 Suppl 3. P. 11–144. |
| [13] |
Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of vilon and epithalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med. 2002;133(3):293–299. EDN: LHIDMD doi: 10.1023/A:1015859322630 |
| [14] |
Anisimov S.V., Bokheler K.R., Khavinson V.Kh., Anisimov V.N. Studies of the effects of vilon and epithalon on gene expression in mouse heart using DNA-microarray technology // Bull Exp Biol Med. 2002. Vol. 133, N 3. P. 293–299. EDN: LHIDMD doi: 10.1023/A:1015859322630 |
| [15] |
Khavinson V, Shataeva L. Model of complementary interaction of short peptides with the DNA double helix. Medical Academic Journal. 2005;5(1):15–23. (In Russ.) |
| [16] |
Хавинсон В.Х., Шатаева Л.К. Модель комплементарного взаимодействия коротких пептидов с двойной спиралью ДНК // Медицинский академический журнал. 2005. T. 5, № 1. C. 15–23. |
| [17] |
Khavinson V, Shataeva L, Chernova A. DNA double-helix binds regulatory peptides similarly to transcription factors. Neuro Endocrinol Lett. 2005;26(3):237–241. |
| [18] |
Khavinson V., Shataeva L., Chernova A. DNA double-helix binds regulatory peptides similarly to transcription factors // Neuro Endocrinol Lett. 2005. Vol. 26, N 3. P. 237–241. |
| [19] |
Khavinson VKh, Tarnovskaya SI, Linkova NS, et al. Short cell-penetrating peptides: a model of interactions with gene promoter sites. Bull Exp Biol Med. 2013;154(3):403–410. doi: 10.1007/s10517-013-1961-3 |
| [20] |
Khavinson V.Kh., Tarnovskaya S.I., Linkova N.S., et al. Short cell-penetrating peptides: a model of interactions with gene promoter sites // Bull Exp Biol Med. 2013. Vol. 154, N 3. P. 403–410. doi: 10.1007/s10517-013-1961-3 |
| [21] |
Khavinson VKh, Popovich IG, Linkova NS, et al. Peptide regulation of gene expression: a systematic review. Molecules. 2021;26:7053. doi: 10.3390/molecules26227053 |
| [22] |
Khavinson V.Kh., Popovich I.G., Linkova N.S., et al. Peptide regulation of gene expression: a systematic review // Molecules. 2021. Vol. 26. P. 7053. doi: 10.3390/molecules26227053 |
| [23] |
Kolchina N, Khavinson V, Linkova N, et al. Systematic search for structural motifs of peptide binding to double-stranded DNA. Nucleic Acids Res. 2019;47(20):10553–10563. doi: 10.1093/narlgkz850 |
| [24] |
Kolchina N., Khavinson V., Linkova N., et al. Systematic search for structural motifs of peptide binding to double-stranded DNA // Nucleic Acids Res. 2019. Vol. 47, N 20. P. 10553–10563. doi: 10.1093/narlgkz850 |
| [25] |
Fedoreyeva LI, Dilovarova TA, Ashapkin VV, et al. Short exogenous peptides regulate expression of CLE, KNOX1, and GRF family genes in Nicotiana tabacum. Biochemistry (Mosc). 2017;82(4):521–528. EDN: YREFSL doi: 10.1134/S0006297917040149 |
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Федореева Л.И., Диловарова Т.А., Ашапкин В.В. и др. Короткие экзогенные пептиды регулируют экспрессию генов семейств CLE, KNOX1 и GRF у Nicotiana tabacum // Биохимия. 2017. Т. 82, № 4. С. 700–709. EDN: YREFSL doi: 10.1134/S0006297917040149 |
| [27] |
Khavinson VKh. Peptides, genome, aging. Moscow: RAN; 2020. 58 p. (In Russ.) EDN: UCSFZP |
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Хавинсон В.Х. Пептиды, геном, старение. Москва: РАН, 2020. 58 с. EDN: UCSFZP |
| [29] |
Khavinson VKh, Rudskoy AI, editors. Peptides and genome: molecular mechanisms of neuroprotetion. Saint Petersburg: POLYTECH-PRESS; 2022. 97 p. |
| [30] |
Пептиды и геном: молекулярные механизмы нейропротекции / под ред. В.Х. Хавинсона, А.И. Рудского. Санкт-Петербург: ПОЛИТЕХ-ПРЕСС, 2022. 97 с. |
| [31] |
Anisimov VN, Arutjunyan AV, Khavinson VKh. Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. Neuro Endocrinol Lett. 2001;22(1):9–18. |
| [32] |
Anisimov V.N., Arutjunyan A.V., Khavinson V.Kh. Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals // Neuro Endocrinol Lett. 2001. Vol. 22, N 1. P. 9–18. |
| [33] |
Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector from the pineal gland inhibits rapid aging of elderly people: results of 15-year follow-up. Bull Exp Biol Med. 2011;151(3):366–369. EDN: OHTSQF doi: 10.1007/s10517-011-1332-x |
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Коркушко О.В., Хавинсон В.Х., Шатило В.Б., Антонюк-Щеглова И.А. Пептидный геропротектор из эпифиза замедляет ускоренное старение пожилых людей: результаты 15-летнего наблюдения // Бюллетень экспериментальной биологии и медицины. 2011. Т. 151, № 3. С. 343–347. EDN: OHTSQF doi: 10.1007/s10517-011-1332-x |
| [35] |
Khavinson VKh, Kuznik BI, Ryzhak GA. Peptide geroprotectors — epigenetic regulators of the physiological functions of the organism. Saint Petersburg: Herzen University; 2014. 271 p. (In Russ.) EDN: YSSNLD |
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Хавинсон В.Х., Кузник Б.И., Рыжак Г.А. Пептидные геропротекторы — эпигенетические регуляторы физиологических функций организма. Санкт-Петербург: РГПУ им. А.И. Герцена, 2014. 271 с. EDN: YSSNLD |
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Korkushko OV, Khavinson VKh, Butenko GM, Shatilo VB. Peptide preparations of the thymus and pineal gland in the prevention of accelerated aging. Saint Petersburg: Nauka; 2002. 202 p. (In Russ.) |
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Коркушко О.В., Хавинсон В.Х., Бутенко Г.М., Шатило В.Б. Пептидные препараты тимуса и эпифиза в профилактике ускоренного старения. Санкт-Петербург: Наука, 2002. 202 с. |
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Khavinson VKh, Kuznik BI, Volchkov VA, et al. Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19. Clinical medicine (Russian journal). 2020;98(8):593–599. EDN: EQFRUJ doi: 10.30629/0023-2149-2020-98-8-593-599 |
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Хавинсон В.Х., Кузник Б.И., Волчков И.А. и др. Влияние тималина на адаптивный иммунитет в комплексной терапии больных COVID-19 // Клиническая медицина. 2020. Т. 98, № 8. С. 593–599. EDN: EQFRUJ doi: 10.30629/0023-2149-2020-98-8-593-599 |
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Khavinson Kh, Mikhailova ON. Health and aging in Russia. In: Robinson M, Novelli W, Pearson C, Norris L, editors. Global Health and Global Aging. AARP Foundation, Jossey-Bass, USA; 2007. P. 226–237. |
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Khavinson Kh., Mikhailova O.N. Health and aging in Russia. In: Global Health and Global Aging. M. Robinson, W. Novelli, C. Pearson, L. Norris., editors. AARP Foundation, Jossey-Bass, USA, 2007. P. 226–237. |
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Anisimov VN, Khavinson VKh, Mikhailova ON. Biogerontology in Russia: from past to future. Biogerontology. 2011;12(1):47–60. EDN: OIBALZ doi: 10.1007/s10522-010-9307-2 |
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Anisimov V.N., Khavinson V.Kh., Mikhailova O.N. Biogerontology in Russia: from past to future // Biogerontology. 2011. Vol. 12, N 1. P. 47–60. EDN: OIBALZ doi: 10.1007/s10522-010-9307-2 |
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