THE INFLUENCE OF DYSLIPIDEMIA ON PARAMETERS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH STABLE ANGINA PECTORIS

Abstract

Study objective: To determine the features of cellular and humoral immune responses in patients with stable angina pectoris (SA) having different degrees of coronary vascular bed impairments. Materials and methods: In a group comprising 67 SA patients aged 60,1±10,1 years, coronary angiography and clinical blood tests were performed, lipid profile was determined, and cellular and humoral immune responses were studied. Results: Increased blood lipid atherogenicity index (BLAI) is associated with increased circulatory immune complexes (CIC) at p<0,05. In IHD patients having myocardium antigen titer score (MATS) from 3 to 8, BLAI is significantly higher than in IHD patients whose MATS is 1 to 2 (p<0,05). Myocardium antigen level increases with increasing blood tryglycerides (p<0,05). Increased LDP and total cholesterol were associated with increased leucocyte migration inhibition index (LMI) (r=0,35 at р<0,05 and r=0,41 at р<0,05, respectively). Lipid profile normalization helps to decrease MATS (p<0,05) and ILMI (p<0,05). Conclusion: The data suggest that dyslipidemia adversely influences IHD by activating inflammatory responses of both types, cellular and humoral.

Keywords

atherosclerosis / theory of atherogenesis / pathogenesis of cardiovascular diseases / inflammatory responses in atherosclerosis

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RIGHTS & PERMISSIONS

Shcheglov D.S., Dudanov I.P., Shcheglova L.V., Avdeeva M.V.