PECULIARITIES OF MYOCARDIUM REMODELING UNDER ADRENERGIC AND CHOLINERGIC TYPES OF ACUTE STRESS IN EXPERIMENT

Abstract

This work is about peculiarities of myocardium structural remodeling and fibrogenesis under different types of acute stress. Cardiomycites density decreasing (mostly in right ventricle) under both of acute stress types was revealed. Extracellular space volume significantly increased under cholinergic stress, especially in right ventricle. Collagen density significantly increased in both of ventricles under both types of stress, but was more pronounced under adrenergic one. Authors have shown equal FGF-2 expression increasing in both of ventricles under both types of stress, but number of producing FGF-2 endotheliocytes in ventricular vessels under adrenergic stress is 3 times higher in comparison with cholinergic one. Expression index of ТGF-β 1 under cholinergic stress is 6 times as much as under adrenergic. Number of producing ТGF-β 1 endotheliocytes increases in 3,5 times in left ventricle and in 5,5 times in the right one comparatively to adrenergic stress. May be, this is conducive to more significant changes in myocardium vessels under cholinergic stress beside adrenergic one. Collagen I type is produced more under cholinergic stress, than under adrenergic one; metalloproteinase-1 almost is not produced under adrenergic stress type, but some single positive cells were found in cholinergic stress tissue samples.

Keywords

myocardium remodeling / immunohistochemical research / fibrogenesis / acute adrenergic stress / acute cholinergic stress / fibroblasts growth factors / I type collagen / metalloproteinase-1

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RIGHTS & PERMISSIONS

Veber V.R., Lobzin J.V., Rubanova M.P., Gubskaya P.M., Zhmailova S.V., Karev V.E., Rumyantsev Y.E., Ataev I.A., Evseiev M.E.