FRACTIONS OF HEMATOPOIETIC STEM CELLS IN A BLOOD OF RECIPIENTS BEFORE TRANSPLANTATION OF A LIVER AND AFTER IT

Abstract

The results presented in the study provide the first evidence that the proportion of CD133+34 -, CD133+/CD34+ and CD34+133 -cells in a blood of patients with a chronic disease of a liver is regularly changed, and their average number are increasing after liver transplantation. The findings are discussed in a context of a possible physiological role of fractions of cells in maintenance of viability of an organ.

Keywords

liver transplantation / circulating stem cells / concentration / variability

References

[1] Шутко А.Н., Гeрасимова О.А., Екимова Л.П., Жeрeбцов Ф.К. Динамка ангиогенных клеток крови при трансплантации печени // Вестник трансплантологии и искусственных органов. — 2012. — № 4. — С. 40—43

[2] Shoutko A., Ekimova L., Mus V., Sokurenko V. Fluctuations of CD34+ cells number in blood of cancer patients during final year of life // Medical and Health Science Journal (MHSJ). — 2012. — Vol. 13, № 4. — P. 7-13.

[3] Kallis Y.N., Alison M.R., Forbes S.J. Bone marrow stem cells and liver disease // Gut. — 2007. — Vol. 56, № 5. — P. 716-724.

[4] Muraca M., Galbiati G., Vilei M.T. et al. The future of stem cells in liver diseases // Ann. of Hepatology. — 2006. — Vol. 5, № 2. — P. 68-76.

[5] Bhatia M. AC133 expression in human stem cells // Leukemia. — 2001. — Vol. 15, № 11. — P. 1685-1688.

[6] Molinari A., Maric D., Tosato G.A., Berardi C. Adult human circulating CD34-Lin-CD45-CD133-cells can differentiate into hematopoietic and endothelial cells // 2011. — Blood. — Vol. 118, № 8. — P. 2105-2015.

[7] Reichelt H., Barz D., Thude H. CD34+ and CD133+ Primitive Stem Cell Expression in Peripheral Blood: Considering Gender, Age, and Smoking // Transfus Med Hemother. — 2009. — Vol. 36, № 2. — P. 129-134.

[8] Baertschiger R.M., Serre-Beinier V., Morel P. et al. Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver // PLoS One. — 2009. — Vol. 4, № 8. — P. e6657.

[9] Chong P.P., Selvaratnam L., Abbas A.A., Kamarul T. Human peripheral blood derived mesenchymal stem cells demonstrate similar characteristics and chondrogenic differentiation potential to bone marrow derived mesenchymal stem cells // J. Orthop Res. — 2012. — Vol. 30, № 4. — P. 634-642.

[10] Piscaglia A.C., Campanale M., Gasbarrini A., Gasbarrini G. Stem cell-based therapies for liver diseases: state of the art and new perspectives // Stem Cells International. — 2010. — Vol. Article ID25946.

[11] Conigliaro A., Brenner D.A., Kisseleva T. Hepatic progenitors for liver disease: current position // Stem Cells and Cloning: Advances and Applications. — 2010. — Vol. 3. — P. 39-47.

[12] Fliedner T.M., Graessle D.H. Hematopoietic cell renewal system: mechanisms of coping and failing after chronic exposure to ionizing radiation // Radiation and Environmental Biophysics. — 2008. — Vol. 47, № 1. — P. 63-69.

[13] Fritzenwanger M., Lorenz F., Jung C. et al. Differential number of CD34+, CD133+ and CD34+CD133+ cells in peripheral blood of patients with congestive heart failure // Eur. J. Med. Res. — 2009. — Vol. 14, № 3. — P. 113-117.

[14] Liu Q. Role of cytokines in the pathophysiology of acute-on-chronic liver failure // Blood Purification. — 2009. — Vol. 28, № 4. — P. 331-341,

[15] Kuci S., Kuci Z., Schmid S. et al. Efficient in vitro generation of adult multipotent cells from mobilized peripheral blood CD133+ cells // Cell Prolif. — 2008. — Vol. 41, № 1. — P. 12-27.

[16] Strick-Marchand H., Masse G.X., Weiss M.C., Di Santo J.P. Lymphocytes Support Oval Cell-Dependent Liver Regeneration // J. of Immunology. — 2008. — Vol. 181, № 4. — P. 2764-2771.

[17] Zhou P., Wirthlin L., McGee J. et al. Contribution of human hematopoietic stem cells to liver repair // Semin Immunopathol. — 2009. — Vol. 31, № 3. — P. 411-419.

[18] Pilat N., Unger L., Berlakovich G.A. Implication for Bone Marrow Derived Stem Cells in Hepatocyte Regeneration after Orthotopic Liver Transplantation // Int. J. of Hepatology. — 2013. — Vol. 2013. Article ID 3106127. — P. 1-7.

[19] Takede T., Sekine K., Enomure M. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant // Nature. — 2013. — № 4. — P. 481-484.

RIGHTS & PERMISSIONS

Shoutko A.N., Gerasimova O.A., Yeimova L.P., Granov A.M.