HEALTH STATUS AND SOME GENOTYPIC FEATURES OF BA MOTHERS' BORN KIDS

M V Vakharlovskaya; M A Petrova; O V Lavrova; T E Ivaschenko; G B Fedoseev; L A Jelenina

doi:10.17816/MAJ13259-63

Medical academic journal ›› 2013, Vol. 13 ›› Issue (2) : 59 -63. DOI: 10.17816/MAJ13259-63

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HEALTH STATUS AND SOME GENOTYPIC FEATURES OF BA MOTHERS' BORN KIDS

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Abstract

117 BA pregnant women and their kids were followed up and treated within 5 to 10 years. Kids' health status was estimated up to end of follow up. Аllergic pathology level within BA mothers' born kids was significantly higher, than in whole population (52,9% & 25%). Main risk factors of allergic pathology appearance within first 7 years of life are: allergic diseases in both parents (p=0,08), infantile phenotype of BA in kids' mother, (p<0,05), weak genotype of IL-4 (-590 C/T), IL-4R (Q576R), TNF-α (-308G>A) genes. Molecular-genetic study of atopic causal genes could be recommended for allergic risk screening in kids in order to perform further diagnostics and prophylaxis.

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bronchial asthma / pregnancy / kids / genomic polymorphism

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M V Vakharlovskaya, M A Petrova, O V Lavrova, T E Ivaschenko, G B Fedoseev, L A Jelenina. HEALTH STATUS AND SOME GENOTYPIC FEATURES OF BA MOTHERS' BORN KIDS. Medical academic journal, 2013, 13(2): 59-63 DOI:10.17816/MAJ13259-63

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