THE IMPORTANCE OF TRANSCRIPTION FACTORS STAT6, STAT4, GATA-3 AND T-bet COOPERATION WHEN BRONCHIAL ASTHMA HAS BEEN DIAGNOSED

Abstract

Lymphocyte signal systems cross-talk interactions present complex net consisting of receptors, enzymes and transcription factors. Using Western blotting for analyzing STAT6, STAT4, GATA-3 and T-bet content in mononuclears, derived from 96 asthma patient and 20 healthy persons, we revealed increase of STAT6 and GATA-3 levels and decrease of STAT4 and T-bet levels in asthma patients, what is obviously may be explained by disturbing of balance in Th1/Th2 regulation interactions. Besides, decrease in STAT4 and T-bet expression in allergic asthma patients was shown, what may indicate malfunction of lL-12-signal-ing pathway in allergic asthma. It may be supposed, that revealed changes in analyzed transcription factors expression levels are connected with clinical and pathogenetic asthma features and probably reflect genetic determination of biology defects.

Keywords

T-bet / GATA-3 / STAT6 / STAT4 / Th1 / Th2 / lL-12 / lL-4 / T-bet / GATA-3 / STAT6 / STAT4 / asthma / mononuclears / Th1 / Th2 / transcription factor / lL-12 / lL-4

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RIGHTS & PERMISSIONS

Trophimov V.I., Mineyev V.N., Sorokina L.N., Nema M.A., Lim V.V., Yeremeyeva A.V.