GENOME POLYMORPHISM STREPTOCOCCUS DYSGALACTIAE SUBSPECIES EQUISIMILIS

Abstract

Streptococcus dysgalactiae subspecies equisimilis is the most wide-spread representative of group G streptococci and an essential aetiologic agent of most human deseases. Despite of the published genome-wide sequence of S. dysgalactiae subsp. equisimilis, there are almost no data on the genetic heterogeneity of this subspecies provided in the present-day literature. This document provides for the comparative analysis of a vast collection of S. dysgalactiae subsp. equisimilis strains isolated in various geographic regions. Virulence genes scpG, lmb, nga, speG and ska have been analyzed for presence. High-grade heterogeneity of scpG gene has been detected. Some strains have been subjected to emm-genotyping. Strains have been analyzed through the pulsed-field electrophoresis. As a result, the significant genome polymorphism of S. dysgalactiae subsp. equisimilis was found out.

Keywords

Streptococcus dysgalactiae subspecies equisimilis / pathogenic streptococcis / Streptococcus dysgalactiae subspecies equisimilis / pulsed-field electrophoresis / virulence genes / genome polymorphism

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RIGHTS & PERMISSIONS

Uliasov Y.Y., Dmitriev A.V.