OVARIAN AROMATASE P450 IN POLYCYSTIC OVARY SYNDROME

Abstract

The objective of this study was the analysis the role of ovarian aromatase P450 in the pathogenesis of polycystic ovary syndrome. The study included 30 patients with normogonadotropic anovulation due to polycystic ovary syndrome (PCOS). The comparison group included 29 women with intact ovulatory menstrual cycle. The expression of aromatase р450 by ovarian granulose cells was determined using immunohistochemical method by 10-12 day menstrual cycle, and determination of total aromatase activity using letrozole probe on day 2-3 of the menstrual cycle. Deficiency of ovarian aromatase in the PCOS was associated with a significantly smaller maximal follicle, while the total aromatase activity does not exceed of physiological limits in healthy women. Results relate ovarian aromatase deficiency characteristic of PCOS with the regulatory disruption, including hyperproduction of luteinizing hormone by the pituitary gland

Keywords

polycystic ovary syndrome / ovarian and total P450 aromatase

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RIGHTS & PERMISSIONS

Savina V.A., Kvetnoy I.M., Kleshchev M.A., Poteen V.V., Rulev V.V., Tarasova M.A., Tkachenko N.N., Jarmolinskaya M.I.