Hormonal markers assessment (leptin, ACTH, cortisol, testosteron) after surgical correction of abdominal obesity

Abstract

The treatment results of 181 patients with abdominal obesity were assessed. 109 patients underwent surgical treatment of abdominal obesity - anterior abdominal lipectomy, 72 were treated conservatively. Surgical group of patients with obesity stage 1-2 showed decrease in leptin, cortisol and testosterone concentration in 1 year after surgery, but surgical patients with obesity stage 3 and conservatively treated patients showed no changes in concentrations of studied hormones. There were no changes of ACTH concentration in both groups. Hormonal status normalization assume body mass stabilization and maintenance.

Keywords

obesity / lipectomy / leptin / ACTH / cortisol / testosterone

References

[1] Благосклонная Я.В., Красильникова Е.И., Бабенко А.Ю. Ожирение и его потенциальная роль в развитии метаболического синдрома. Лечение // Врач, вед. 1999. № 1 (7). С. 34-36.

[2] Hansen Е., Hajrit, Abumrod N.N. Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus // Surgery. 2006. Jun. Vol. 139(6). P.711-716.

[3] I-Ieymsfield S.B., Greenberg A.S., Fujioka K. et al. Recombinant leptin for weight loss in Obese and Lean Adults. A randomized, Controlled, Dose escalation trial //YAMA. 1999. Vol. 282. P. 1568-1575.

[4] Juhasz A., Katone E., Csongradi E., Paragh G. A practicing physician’s view on obesity // Orv. Hetil. 2006. Vol. 147. P. 579-590.

[5] Masuzaki H., Ogawa Y., Isse N., Satoh N.T. et al. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue // Diabetes. 1995. Vol. 44. P. 855-858.

[6] Muller G. et al. Leptin impairs metabolic actions of insulin in isolated rat adipocytes // J. Biol. Chem. 1997. Vol. 272. № 16. P. 10585-10593.

[7] Lee J.M., Kim S.R., Yoo S.J. et al. The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes // J. Int. Med. Res. 2009. Vol. 37 (6). P. 1803-1812.

[8] Sihna M.K., Ohannesian J.P., Heiman M.L. et al. Nocturnal rise of leptin in lean, obese, and non-insulin-de- pendent diabetes mellitus subjects // J. Clin. Invest. 1997. Vol. 97. P. 1344-1347.

[9] Tartaglia L.A., Demski M., Weng X. et al. Identification and expression cloning of a leptin receptor Ob-R //Cell. 1995. Vol. 83. P. 1263-1271.

[10] Zhao W.G., Zhu H.J. Mechanism, treatment and Evaluation of obesity-induced insulin resistance and type 2 diabetes // Zhongguo. 2010. Vol. 32. P. 7-12.

RIGHTS & PERMISSIONS

Volokh M.A., Khalimov Y.S.