Antiviral activity of adamantane derivatives against respiratory syncytial virus

Abstract

BACKGROUND: Respiratory syncytial infection annually affects large segments of the population around the world. Despite the ease of clinical manifestations in most adults, for children under two years of age, this disease is a serious danger, leading to the development of severe bronchiolitis, even death.

AIM: The aim of this study was to search for drugs with antiviral activity among adamantane derivatives.

MATERIALS AND METHODS: Preparations of the group of adamantane derivatives were synthesized in the Department of Medicinal Chemistry of Natural Compounds of the N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS. The cytotoxicity and antiviral activity of the compounds were studied in HEp-2 cell culture using the MTT test and enzyme immunoassay, respectively.

RESULTS: There were no drugs with high antiviral properties against RSV in this group.

CONCLUSIONS: Despite the absence of drugs with pronounced anti-RSV properties, the information obtained in the course of the work can be used for a targeted search for antitumor substances.

Keywords

respiratory-syncytial virus / adamantanes / antiviral activity / cell culture

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