Professor P.P. Denisenko and his school: a scientific biography and personal recollections

Abstract

Pyotr Prokofyevich Denisenko (1923–2011) was a distinguished Russian pharmacologist, Doctor of Medical Sciences, Professor, and Honored Scientist of the RSFSR. A veteran of the Great Patriotic War (1941–1945), he was awarded with 11 military honors. For 26 years (1963–1989), he served as the head of the Department of Pharmacology at the Sanitary and Hygienic State Medical Institute of the Ministry of Health of the RSFSR. He is widely recognized for his pioneering research on synaptic transmission pharmacology and the cholinergic mechanisms regulating bodily functions. Denisenko authored groundbreaking studies and monographs, including Gangliolytics (1959), Central Cholinolytics (1965), and The Role of Cholinoreactive Systems in Regulatory Processes (1980). He mentored a generation of Russian pharmacologists, supervising 28 doctoral and 127 candidate dissertations. Denisenko played a direct role in the development of numerous pharmaceuticals, including ganglioblockers (benzhexonium), central cholinolytics (metamizil), anxiolytics (tarden), anti-ischemic agents (etmaben), antiviral drugs (mixovirin), anti-shock agents (mizidol), burn and wound healing treatments (bathizin, santoparin), hepatoprotectors (geranol, polyen, sinabet), peptic ulcer treatments (benzhexonium, labaznik, polyen), antihypoxants (isothiormin), antioxidants (violuric acid), and disinfectants (aquabor). Additionally, he provided the first detailed pharmacological characterization of the natural product mumiyo.

Keywords

P.P. Denisenko / scientific school / pharmacology / cholinergic transmission / pharmaceuticals

References

[1] Shabanov PD, Sapronov NS, editors. Petr Prokofievich Denisenko (on the 90th anniversary of his birth). Saint Petersburg: Art-Xpress; 2013. 88 p. (In Russ.) EDN: YHKAZD

[2] Петр Прокофьевич Денисенко (к 90-летию со дня рождения) / Под ред. П.Д. Шабанова, Н.С. Сапронова. Санкт Петербург: Art-Xpress, 2013. 88 с. EDN: YHKAZD

[3] Denisenko PP. Gangliolytics. Leningrad: Medicine, 1959. 117 p. (In Russ.)

[4] Денисенко П.П. Ганглиолитики. Ленинград: Медицина, 1959. 117 с.

[5] Denisenko PP. Central anticholinergics. Leningrad: Medicine; 1965. 279 p. (In Russ.)

[6] Денисенко П.П. Центральные холинолитики. Ленинград: Медицина, 1965. 279 с.

[7] Denisenko PP. The role of cholinergic reactive systems in regulatory processes. Leningrad: Medicine, 1980. 295 p. (In Russ.)

[8] Денисенко П.П. Роль холинореактивных систем в регуляторных процессах. Ленинград: Медицина, 1980. 295 с.

[9] Anichkov SV. At the turn of two eras. Leningrad: Lenizdat; 1982. 186 p. (In Russ.)

[10] Аничков С.В. На рубеже двух эпох. Лениград: Лениздат, 1982. 186 с.

[11] Shabanov PD. History of the formation of the Pharmacology Department of the Institute of Experimental Medicine (on the 100th anniversary of the department). Psychopharmacology and Biological Narcology. 2023;14(3):169–184. EDN: WUFDFP doi: 10.17816/phbn567967

[12] Шабанов П.Д. История становления отдела фармакологии Института экспериментальной медицины (к 100-летию отдела) // Психофармакология и биологическая наркология. 2023. Т. 14, № 3. С. 169–184. EDN: WUFDFP doi: 10.17816/phbn567967

[13] Ignatov YuD, Sapronov NS, Shabanov PD, editors. Pharmacology in St. Petersburg (historical essays). Saint Petersburg: Elbi-SPb; 2007. 416 p. (In Russ.)

[14] Фармакология в Санкт-Петербурге (исторические очерки) / Под ред. Ю.Д. Игнатова, Н.С. Сапронова, П.Д. Шабанова. Санкт-Петербург: Элби-СПб, 2007. 416 с.

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