Erythropoietin as antihypoxic cytokine
Andrey V. Lyubimov , Diana D. Bykova , Anton S. Tarachteev , Evgeniy V. Ivchenko , Semen V. Efimov
Psychopharmacology & biological narcology ›› 2024, Vol. 15 ›› Issue (1) : 33 -39.
Erythropoietin as antihypoxic cytokine
This study analyzed the potential for the widespread use of erythropoietin, the main antihypoxic cytokine produced by renal parenchyma cells, and possible complications associated with its use. Erythropoietin is a glycoprotein heterodimer whose main function is the regulation of the formation and differentiation of erythroid germ cells and formation of the primary physiological response to hypoxia. The main effects of this cytokine are summarized, and the main points of application of the hormone, mechanisms of content regulation, and its use in medicine as a natural pharmacological agent in pharmacological preconditioning are highlighted. Attention is also drawn to the increasing role of hypoxia — one of the most dangerous typical pathological processes in the formation of life-threatening conditions, which has found its use in medicine, particularly as a physiological agent in combating vascular diseases, which are gaining enormous importance in our time.
hypoxia / erythropoietin / pharmacological preconditioning / erythrocyte / hypoxia-inducible factor 1
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