The Development of Male Sexual Function after Prenatal Modulation of Cholinergic System

Abstract

Bairamov AA. [The Development of Male Sexual Function after Prenatal Modulation of Cholinergic System]. Psychopharmacol Biol Narcol. 2009; 9(1-2). Epub 2009 May 04. Russian.Prenatal exposure of N-cholinolytic gangleron compared with M-cholinolytic methamyzil to pregnant rat females at 9-19 days of pregnancy produced the long-term behavioral changes in pubescent rat progenies. Pubescent rat progenies had got the low dynamics of gaining sexual experience and decreased sexual activity with equal disturbance of motivation and coitus. The quantity of males with reduced sexual activity was more compared with the control group. It is suggested that sexual dysfunction of adulthood offsprings is provoked by introduction of gangleron (N-cholinolytic) which was injected at 9-11 and 12-14 days of gestation, and methamyzil (M-cholinolytic) injected at 9-11 days of gestation. We suppose that the regulation of neuronal mechanisms for sexual function is disturbed as a consequence of long-term changings in neurotransmitter activity (first of all in the dopaminergic activity) in the hippocampus and hypothalamus. Therefore, in brain limbic structures was mostly affected. The second reason of the reduced sexual activity in the offsprings is the decrease of the blood testosterone. [in Russian with English Summary].Сitation: Psychopharmacol Biol Narcol. 2009; 9(1-2): 2530-2539

Keywords

cholinolytics / prenatal exposure / sexual behavior / neurotransmitters / testosterone / rats' progeny / long-term effects

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