Induction of Neuraminidase Activity in Neural Cells in Vitro by Synthetic Analogues of cAMP

Sergey Nikolaevich Proshin , Evgeniy Rudol'fovich Bychkov , Andrey Andreevich Lebedev , Galina P Kosyakova , Petr Dmitrievich Shabanov , S N Proshin , E R Bychkov , A A Lebedev , G P Kosyakova , P D Shabanov

Psychopharmacology & biological narcology ›› 2008, Vol. 8 ›› Issue (3-4) : 2434 -2442.

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Psychopharmacology & biological narcology ›› 2008, Vol. 8 ›› Issue (3-4) : 2434 -2442. DOI: 10.17816/phbn322000
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Induction of Neuraminidase Activity in Neural Cells in Vitro by Synthetic Analogues of cAMP

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Abstract

The treatment of human neuroblastoma NB-1 cells by db-cAMP induced the high frequency of neural cells bearing neurite as well as more than two-fold elevated activity of sialidase associated with plasma membrane (SAPM). The elevated silaidase activity was accompanied by increasing the quantity of mRNA for that enzyme as was estimated by RT-PCR. The neural cells with elevated SAPM activity and developed neurite were shown to have high activity of another enzyme (acetylcholinesterase) that is strongly considered as a biochemical marker of neural cell differentiation. Due to our experimental work it has been reasoned that elevated activity of sialidase associated with plasma membrane is closely related to neural cell differentiation and can be considered as a key factor for therapy of disorders connected to damage of cells of neuronal orogon

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neuraminidase / gangliosides / neural cells

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Sergey Nikolaevich Proshin,Evgeniy Rudol'fovich Bychkov,Andrey Andreevich Lebedev,Galina P Kosyakova,Petr Dmitrievich Shabanov,S N Proshin,E R Bychkov,A A Lebedev,G P Kosyakova,P D Shabanov. Induction of Neuraminidase Activity in Neural Cells in Vitro by Synthetic Analogues of cAMP. Psychopharmacology & biological narcology, 2008, 8(3-4): 2434-2442 DOI:10.17816/phbn322000

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