Comparison of Effects Anylocaine and Lidocaine on Ionic Channels of Isolated Neurones of Mollusc
Nadezhda Pavlovna Lisitsyna , Tat'yana Aleksandrovna Petropavlovskaya , Irina Leonidovna Cherednik , Yuriy Dmitrievich Ignatov , Vladimir Ivanovich Pantsurkin , Anatoliy Ivanovich Vislobokov , Konstantin Nikolaevich Mel'nikov , Vera Anatol'evna Borisova , N P Lisitsyna , T A Petropavlovskaja , I L Cherednik , Yu D Ignatov , V I Pantsurkin , A I Vislobokov , К N Melnikov , V А Borisova
Psychopharmacology & biological narcology ›› 2008, Vol. 8 ›› Issue (3-4) : 2426 -2433.
Comparison of Effects Anylocaine and Lidocaine on Ionic Channels of Isolated Neurones of Mollusc
: It was shown that local anesthetics anylocaine and lidocaine in concentration 0.1, 1, 10,100 and 1000 µM in dose-dependent manner suppressed sodium and potassium currents. The amplitude slow potassium currents after action of anesthetics in low concentration (from 0.1 up to 10 µM) grew by 5-10 % in comparison with the control, and after over higher doses was reduced. In concentration 1000 µM the amplitude of all ionic currents was reduced approximately on 50 %, i.e. it was not revealed selectivity of action of the investigated substances on ionic channels. Membranotropic action of anylocaine and lidocaine on neurons can be realized also through influence on nonspecific conductivity of membrane, potential of a superficial charge of membrane near to ionic channels, kinetics of activation or inactivation of ionic currents. Anylocaine by 10-15 % more suppressed sodium and potassium ionic currents than lidocaine, and rendered longer post actions, i.e. more strongly contacted with ionic channels.
local anesthetics / anylocaine / lidocaine / membranetropic action / neurons / ionic currents
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