MORPHOLOGICAL REACTION OF SKIN TO SUBDERMALNY INTRODUCTION OF MONOFILAMENTNY THREADS FROM A POLIDIOKSANON

Abstract

Purpose. To study morphological reaction of skin to subdermalny introduction of monofilamentny threads from a polidioksanon (PDO). Material and methods. The research is conducted on 14 white rats females of 3-months age. To the area of a back, to the right of a spine column, is 2 cm higher than a tail, about 4 threads from a PDO, in parallel each other, at distance of 1-1.5 mm are implanted. Wool in the field of implantation is shaved, rules of an asepsis and antiseptics are observed. 21 days of a rat later are humanely hammered, fragments of skin of 1.5 × 1.5 cm in size are withdrawn for a histologic research. As control intact samples of skin from the opposite side from a spine column are taken. Results. The received results of a morphological research show that use of threads/sutural material from a PDO has well expressed stimulating effect on collagenogenesis and angiogenesis. For 21 days after introduction of PDO of threads increase in the regenerator activity of cages of a fibroblastichesky row with increase in synthesis of a fibrous component of an intercellular matriks and also lack of ekssudativny inflammation which is poorly expressed by inflammatory infiltration by cages only lympho-plasmacytic a row, lack of allergic reaction, formation of granulomas and the expressed fibrosis is noted. It demonstrates to good regenerator activity of fabrics in reply introduction of threads from a PDO in 21 days.

Keywords

biostimulating threads / neoangiogenesis / mesoniti / polydioxanone / morphological changes

References

[1] Аравийская Е.Р. Возрастные изменения в дерме: новые сведения и пути коррекции с помощью средств ежедневного ухода. Русский медицинский журнал. 2008; 16(8): 574-575.

[2] Гелашвили П.А., Супильников А.А., Плохова В.А. Кожа человека (анатомия, гистология, гистопатология). Самара: Самарский медицинский институт «Реавиз»; 2013.

[3] Имаева Н.А., Потекаев Н.Н., Ткаченко С.Б., Шугинина Е.А. Особенности нарушения микроциркуляции при различных типах старения кожи. Кардиоваскулярная терапия и профилактика. 2008; 7(3): 107-110.

[4] Дубовик А.А. Кровоснабжение кожи пожилых людей. Косметические средства. 2016; (4): 4-9.

[5] Соловьева Е.В., Юсова Ж.Ю., Иванова М.А. Инволюционные изменения кожи и микроциркуляторного русла. Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. 2012; 20 (22-2): 97-100.

[6] Петров В.В. Клетки и кровеносные сосуды дермы человека в онтогенезе. Казань; 2015.

[7] Ахтямов С.Н., Кягова А.А. Клинико-морфологические особенности старения кожи. Вестник дерматологии и венерологии. 2005; (4): 60-4.

[8] Мантурова Н.Е., Городилов Р.В., Кононов А.В. Старение кожи: механизмы формирования и структурные изменения. Анналы пластической, реконструктивной и эстетической хирургии. 2010; (1): 88-92.

[9] Головатая И.В., Неробеев А.А., Радион Е.В. Нитевые технологии: взаимодействие биорезорбируемых нитей с мягкими тканями. Kosmetik International. 2015; (3): 100-106.

[10] Amuso D., Amore R., Iorio E.L., Dolcemascolo R., Bonetti L., Leonardi V. Histological evaluation of a biorevitalisation treatment with PDO wires. Aesthet. Med. 2015; 1(3): 111-7

[11] Lee H., Yoon K., Lee M. Outcome of facial rejuvenation with polydioxanone thread for Asians. J. Cosmet. Laser Ther. 2018; 20(3): 189-92.

[12] Kurita M., Matsumoto D., Kato H., Araki J., Higashino T., Fujino T., et al. Tissue reactions to cog structure and pure gold in lifting threads: a histological study in rats. Aesthet. Surg. J. 2011; 31(3): 347-51.

[13] Moulonguet I., Arnaud E., Plantier F., da Costa P., Zaleski S. Histopathologic and ultrastructural features of gold thread implanted in the skin for facial rejuvenation. Am. J. Dermatopathol. 2015; 37(10): 773-7.

[14] Kim H., Bae I.H., Ko H.J., Choi J.K., Park Y.H., Park W.S. Novel polydioxanone multifilament scaffold device for tissue regeneration. Dermatol. Surg. 2016; 42(1): 63-7.

[15] Suh D.H., Jang H.W., Lee S.J., Lee W.S., Ryu H.J. Outcomes of polydioxanone knotless thread lifting for facial rejuvenation. Dermatol. Surg. 2015; 41(6): 720-5.

[16] Yun H.J., Lee H.J. Numerous linear metallic densities on radiograph: Gold threads. J. Postgrad. Med. 2016; 62(3): 208. doi: 10.4103/0022-3859.168267.

[17] Кодяков А.А., Федоров П.Г. Тенденции эстетической медицины и нитевые методы омоложения. Инъекционные методы в косметологии. 2017; (1): 4-10

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