RESULTS OF OXYGEN-OZONE MIX IN THE TREATMENT OF VITILIGO

Abstract

Obtaining new data on the role of the antioxidant system in vitiligo in the future can contribute to the development of new effective and safe methods for combining vitiligo with an oxygen-ozone mixture with a minimal risk of side effects, as well as a short duration of treatment and low financial costs. Materials and methods. We observed 50 patients with vitiligo in the advanced stage of the disease, aged 20-59 years. Before the start of the course of ozonotherapy and after its completion in 2-4 weeks, the main indicators of the antioxidant system were studied (the following superoxide dismutase, glutathione peroxidase, glutathione, malonic dialdehyde, 8-OH-deoxyguanosine). All patients received systemic oxygen-ozone mixture therapy by intravenous injection of ozonized saline (OBS). The amount of the injected solution is 300-400 ml, the duration of the procedure is 30-60 minutes. The procedures performed 3 times a week; the course is 9-10 procedures. The tolerability of the procedures was satisfactory in all cases, no side effects were observed. Results. As a result of the treatment the stop of the progression of vitiligo was noted in 40 (80%) patients in the form of diffuse or point repigmentation, a decrease in the area of depigmented spots. This clinical picture correlated with the normalization of the indices of oxidative stress, which was manifested by a significant decrease in the level of malonic dialdehyde and 8-OH-deoxyguanosine against a background of an increase in the concentration of glutathione and glutathione peroxidase on average in 1.5 times.

Keywords

vitiligo / oxygen-ozone therapy / antioxidant system / oxidative stress / superoxide dismutase / glutathione peroxidase / malon dialdehyde / 8-oxo-deoxyguanozine / glutathione

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