Unactivated platelet leukocyte autoplasma in the treatment of non scarring alopecia

Abstract

The literature review of the cellular functioning mechanisms of the hair follicles, the role of stem cells in the life cycle of the hair, the major effects of growth factors are presented. Authors, patented treatment method of non scarring alopecia is described. The technology ofpreparation and method of use of unactivated platelet leukocyte autoplasma in various forms of alopecia are described. Own clinical observation of 60 patients with non scarring alopecia and results of their unactivated platelet leukocyte autoplasma are presented. 80% of patients had a clinical cure. Investigations of platelet concentration, white blood cells and growth factors in platelet-rich plasma and platelet leukocyte unactivated autoplasma were performed. The results are shown in the article.

Keywords

hair / growth factors / non scarring alopecia / inactivated platelet leukocyte autoplasma

References

[1] Олисова О.Ю., Егорова К.Г. Богатая тромбоцитами плазма в терапии нерубцовых алопеций. Российский журнал кожных и венерических болезней. 2014; 17(6): 60-2.

[2] Баткаев Э.А., Галлямова Ю.А., Хассан Аль-Хадж Халед. Диффузная алопеция. Методическое пособие. М.: Российская медицинская академия последипломного образования; 2010.

[3] Нажмутдинова Д.К., Таха Т.В. Алопеция: диагностика и лечение. Медицинский совет. 2010; 5-6: 87-91.

[4] Semenova E., Koegel H., Hasse S., Klatte J.E., Slonimsky E., Bilbao, D., et al. Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am. J. Pathol. 2008; 173(1): 14-24.

[5] Sommeling C., Heyneman A., Hoeksema H., Verbelen J., Stillaert F.B., Monstrey S., et al. The use of platelet-rich plasma in plastic surgery: A systematic review. J. Plast. Reconstr. Aest. Surg. 2013; 40(5): 301-4.

[6] Weger N., Schlake T. Igf-I signalling controls the hair growth cycle and the differentiation of hair shafts. J. Invest. Dermatol. 2005; 125(5): 873-82.

[7] Kawano M., Komi-Kuramochi A., Asada M., Suzuki M., Oki J., Jiang J., et al. Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. J. Invest. Dermatol. 2005; 124(5): 877-85.

[8] Marx R.E. Platelet-rich plasma: evidence to support its use. J. Oral. Maxillofac. Surg. 2004; 62(4): 489-96.

RIGHTS & PERMISSIONS

Eco-Vector