The role of ecology in the region of residence of patients with epidermolysis bullosa and during the experiment

Abstract

BACKGROUND: A person is constantly influenced by the environment, which determines his state of health. Animal testing is used to determine the danger of certain chemical agents of inanimate nature. To extrapolate the experimental result to humans, the body of patients with the dystrophic form of epidermolysis bullosa, which has a low threshold of resistance to aggressive stimuli, is preferable.

AIM: To study the impact of anthropogenic physicochemical factors on the skin of white mice, as well as environmental ecology on the population of patients with the dystrophic form of congenital epidermolysis bullosa.

MATERIALS AND METHODS: Scientific research is both observational and interventional. The observational part of the study included patients suffering from dystrophic form of epidermolysis bullosa. There are white mice in the interventional part.

RESULTS: Seeding with agrochemicals causes skin eczema, periorbital dermatitis, finger mutation and contracture, claw deformity and chronic itching in white mice. The possibility and criteria for extrapolating the results of the experiment to patients suffering from dystrophic form of epidermolysis bullosa have been established. These criteria include: itching of the skin, mutation and pseudosyndactyly of the fingers. The effect on the body of patients with dystrophic form of epidermolysis bullosa with toxic agents was carried out by the living environment. It has been established that in order to achieve the positive effect of complex therapy, in addition to highly qualified medical care, an environmentally safe living environment is necessary. Traveling and living in conditions that do not pose an environmental danger to humans helps to reduce the severity of the disease and improve their quality of life.

CONCLUSION: The ecology of the living environment determines the effectiveness of therapy in patients with dystrophic form of epidermolysis bullosa, as well as the timing of manifestation and severity of the disease. A healthy environment contributes to the epithelization of ulcerative elements and the disappearance of itching.

Keywords

ecology / mice / experiment / epidermolysis bullosa

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Funding

Dagestan State Medical University of the Ministry of Health of the Russian FederationФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России

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