Human papillomavirus and its association with oral lichen planus

Abstract

BACKGROUND: Oral lichen planus is a chronic disease with periods of exacerbations and remissions, requiring long-term symptomatic treatment and observation. Dermatosis can occur or worsen in the presence of different triggers, for example, due to the persistence of the human papillomavirus.

AIM: to explore the effect human papillomavirus on the characteristics oral lichen planus.

MATERIALS AND METHODS: 90 patients with oral lichen planus aged from 26 to 73 years (average age 55.61±1.00 years) were examined. Real-time polymerase chain reaction was used to detect human papillomavirus. The need for treatment of caries, Green–Vermillion and complex periodontal indices were used to analysis state of oral hygiene.

RESULTS: Human papillomavirus DNA was detected in 53 (58.88%) cases. Patients of this group were 4 years younger than other study participants; the duration of dermatosis is 2 years longer with a predominance of atrophic/erythematous and erosive/ulcerative forms. It was noted that indexes of caries and the complex periodontal were significantly (p=0,007 and p=0,030 respectively) higher compared to patients without papillomavirus infection.

CONCLUSION: It is found features of oral lichen planus in identifying human papillomavirus: early onset; severe of the disease with predominantly destructive forms; high prevalence of caries and periodontitis.

Keywords

oral lichen planus / oral mucosa / human papillomavirus infection / oral hygiene

References

[1] Vijayan A, Muthukrishnan A, Vidyadharan M, Nair A. Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review. J Pharmacy Bioallied Sci. 2021;13(Suppl 1): 62–S67. doi: 10.4103/jpbs.jpbs_836_20

[2] Vijayan A., Muthukrishnan A., Vidyadharan M., Nair A. Role of human papilloma virus in malignant transformation of oral lichen planus: A systematic review // J Pharmacy Bioallied Sci. 2021. Vol. 13, Suppl. 1. P. S62–S67. doi: 10.4103/jpbs.JPBS_836_20

[3] Villa TG, Sánchez-Pérez Á, Sieiro C. Oral lichen planus: A microbiologist point of View. Int Microbiol. 2021;24(3):275–289. doi: 10.1007/s10123-021-00168-y

[4] Villa T.G., Sánchez-Pérez Á., Sieiro C. Oral lichen planus: A microbiologist point of View // Int Microbiol. 2021. Vol. 24, N 3. P. 275–289. doi: 10.1007/s10123-021-00168-y

[5] Sabirov TK, Sultonov UB. Clinical course of lichen planus. Dermatovenerol Aesthetic Med. 2022;(1-2):10–13. (In Russ).

[6] Сабиров Т.К., Султонов У.Б. Клиническое течение красного плоского лишая // Дерматовенерология и эстетическая медицина. 2022. № 1-2. С. 10–13.

[7] Sood A, Raghavan S, Batra P, et al. Rise and exacerbation of oral lichen planus in the background of SARS-COV-2 infection. Med Hypotheses. 2021;(156):110681. doi: 10.1016/j.mehy.2021.110681

[8] Sood A., Raghavan S., Batra P., et al. Rise and exacerbation of oral lichen planus in the background of SARS-COV-2 infection // Med Hypotheses. 2021. N 156. P. 110681. doi: 10.1016/j.mehy.2021.110681

[9] Zou H, Daveluy S. Lichen planus after COVID-19 infection and vaccination. Arch Dermatol Res. 2022;315(2):139–146. doi: 10.1007/s00403-022-02497-y

[10] Zou H., Daveluy S. Lichen planus after COVID-19 infection and vaccination // Arch Dermatol Res. 2022. Vol. 315, N 2. P. 139–146. doi: 10.1007/s00403-022-02497-y

[11] Galchenko VM. Treatment of complex forms of red flat lichen of the mucous membrane of the cavity. In: The role of science and education in the modernization of modern society: collection of articles of the International Scientific and Practical Conference (December 19, 2019, Orenburg). Part 2. Ufa: Aeterna; 2019. Р. 211–214. (In Russ).

[12] Галченко В.М. Лечение сложных форм красного плоского лишая слизистой оболочки полости // Роль науки и образования в модернизации современного общества: сборник статей Международной научно-практической конференции (19 декабря 2019 г., Оренбург). В 2 ч. Ч. 2. Уфа: Аэтерна, 2019. С. 211–214.

[13] Shang Q, Peng J, Zhou Y, et al. Association of human papillomavirus with oral lichen planus and oral leukoplakia: A meta-analysis. J Evid Based Dental Pract. 2020;20(4):101485. doi: 10.1016/j.jebdp.2020.101485

[14] Shang Q., Peng J., Zhou Y., et al. Association of human papillomavirus with oral lichen planus and oral leukoplakia: A meta-analysis // J Evid Based Dental Pract. 2020. Vol. 20, N 4. P. 101485. doi: 10.1016/j.jebdp.2020.101485

[15] Oberti L, Alberta L, Massimo P, et al. Clinical management of oral lichen planus: A systematic review. Mini Rev Med Chem. 2019;19(13):1049–1059. doi: 10.2174/1389557519666190301144157

[16] Oberti L., Alberta L., Massimo P., et al. Clinical management of oral lichen planus: A systematic review // Mini Rev Med Chem. 2019. Vol. 19, N 13. P. 1049–1059. doi: 10.2174/1389557519666190301144157

[17] Swain SK. Premalignant lesions of the oral cavity: Current perspectives. J Res Med Sci. 2021;9(6):1816. doi: 10.18203/2320-6012.ijrms20212259

[18] Swain S.K. Premalignant lesions of the oral cavity: Current perspectives // J Res Med Sci. 2021. Vol. 9, N 6. P. 1816. doi: 10.18203/2320-6012.ijrms20212259

[19] Wang J, Yang J, Wang C, et al. Systematic review and meta-analysis of oxidative stress and antioxidant markers in oral lichen planus. Oxid Med Cell Longev. 2021;2021: 9914652. doi: 10.1155/2021/9914652

[20] Wang J., Yang J., Wang C., et al. Systematic review and meta-analysis of oxidative stress and antioxidant markers in oral lichen planus // Oxid Med Cell Longev. 2021. Vol. 2021. P. 9914652. doi: 10.1155/2021/9914652

[21] Mohammadi M, Abbaszadeh H, Mohtasham N, et al. The association between high-risk human papillomavirus and oral lichen planus. Clin Exp Dent Res. 2023;9(1):93–99. doi: 10.1002/cre2.707

[22] Mohammadi M., Abbaszadeh H., Mohtasham N., et al. The association between high-risk human papillomavirus and oral lichen planus // Clin Exp Dent Res. 2023. Vol. 9, N 1. P. 93–99. doi: 10.1002/cre2.707

[23] Didona D, Caro RD, Santos AM, et al. Therapeutic strategies for oral lichen planus: State of the art and new insights. Front Med. 2022;(9):997190. doi: 10.3389/fmed.2022.997190

[24] Didona D., Caro R.D., Santos A.M., et al. Therapeutic strategies for oral lichen planus: State of the art and new insights // Front Med. 2022. N 9. P. 997190. doi: 10.3389/fmed.2022.997190

[25] Gileva OS, Koshkin SL, Libik TV, et al. Periodontological aspects of diseases of the oral mucosa: lichen planus. Periodontology. 2017;22(3):9–14. (In Russ).

[26] Гилева О.С., Кошкин С.Л., Либик Т.В., и др. Пародонтологические аспекты заболеваний слизистой оболочки полости рта: красный плоский лишай // Пародонтология. 2017. Т. 22, № 3. С. 9–14.

[27] Shang Q, Peng J, Zhou Y, et al. Association of human papillomavirus with oral lichen planus and oral leukoplakia: A meta-analysis. J Evid Based Dent Pract. 2020;20(4):101485. doi: 10.1016/j.jebdp.2020.101485

[28] Shang Q., Peng J., Zhou Y., et al. Association of human papillomavirus with oral lichen planus and oral leukoplakia: A meta-analysis // J Evid Based Dent Pract. 2020. Vol. 20, N 4. P. 101485. doi: 10.1016/j.jebdp.2020.101485

[29] Elenbaas A, Enciso R, Al-Eryani K. Oral lichen planus: A review of clinical features, etiologies, and treatments. Dent Rev Dent Clin Dent Prospects. 2022;2(1):100007. doi: 10.1016/j.dentre.2021.100007

[30] Elenbaas A., Enciso R., Al-Eryani K. Oral lichen planus: A review of clinical features, etiologies, and treatments // Dent Rev Dent Clin Dent Prospects. 2022. Vol. 2, N 1. P. 100007. doi: 10.5681/joddd.2010.002

RIGHTS & PERMISSIONS

Eco-Vector