Clinical efficacy and characteristics of immunological changes in patients with psoriasis following the combined use of sulfide peloids from Lake Saki

Abstract

BACKGROUND: Psoriasis is a common disease, and many of its forms are resistant to treatment.

AIM: This study aimed to analyze the effects of complex treatment with Lake Saki sulfide peloids on the clinical and immunological parameters patients with psoriasis.

MATERIALS AND METHODS: The study included 90 patients with steady-state psoriasis of mild or moderate severity (51 men and 39 women) aged 23–65 (mean age 37.3 ± 12.7) years, who received treatment at the N.I. Pirogov Saki Military Clinical Health Resort of the Russian Ministry of Defense. The control group consisted of 30 apparently healthy volunteers.

RESULTS: Taking into account the clinical and immunological parameters of patients with mild and moderate psoriasis, we have developed a complex differentiated method of treatment using Lake Saki peloids and brine supplemented with an alpha-lipoic acid preparation.

CONCLUSION: The presented complex method of peloid balneotherapy in combination with alpha-lipoic acid preparation intensifies the 14-day course of sanatorium-resort treatment, increases the duration of remission, and enhances the quality of life of patients with mild-to-moderate psoriasis.

Keywords

psoriasis / dermatological indices / immune and morphological changes / peloids / brine from the Lake Saki / alpha-lipoic acid

References

[1] Kubanov АА, Kubanova АА, Karamova AE, Mineyeva AA. Prevalence of genetic risk factors of psoriasis among the population of the Russian Federation. Bulletin of Dermatology and Venereology. Russian Journal. 2014;90(6):69-76. (in Russian)

[2] Кубанов А.А., Кубанова А.А., Карамова А.Э., Минеева А.А. Распространенность генетических факторов риска псориаза среди населения Российской Федерации // Вестник дерматологии и венерологии. 2014;90(6):69-76.

[3] Michalek IM, Loring В, John S. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad. Dermatol Venereol. 2017;31(2):205-12.

[4] Michalek I.M., Loring В., John S. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad. Dermatol Venereol. 2017;31(2):205-12.

[5] Suskova VS, Pinson IYa, Оlisova OYu. Immunopathological mechanisms of psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2006;4(1):68-70. (in Russian)

[6] Сускова В.С., Пинсон И.Я., Олисова О.Ю. Иммунопатогенез псориаза // Клиническая дерматология и венерология. 2006;4(1):68-70.

[7] Kubanova AA, Kubanov AA, Melekhina LE, Bogdanova EV. The assessment of the incidence of skin disorders in Russian Federation in 2003-2016. Bulletin of Dermatology and Venereology. Russian Journal. 2017;93(6):22-33. (in Russian)

[8] Кубанова А.А., Кубанов А.А., Мелехина Л.Е., Богданова Е.В. Оценка состояния заболеваемости болезнями кожи и подкожной клетчатки в Российской Федерации за период 2003-2016 гг. // Вестник дерматологии и венерологии. 2017;93(6):22-33.

[9] Khairutdinov VR, Belousova IE, SamtsovAV. Immune pathogenesis of psoriasis. Bulletin of Dermatology and Venereology. Russian Journal. 2016;92(4):20-6. (in Russian)

[10] Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В. Иммунный патогенез псориаза // Вестник дерматологии и венерологии. 2016;92(4):20-6.

[11] Samtsov AV, Khairutdinov VR, Bakulev AL, Kubanov AA, Karamova AE, Artemyeva AV, Korotaeva TV. Efficacy and Safety of BCD-085, a Novel Interleukin-17 Inhibitor. Results of Phase II Clinical Trial in Patients with Moderate-to-Severe Plaque Psoriasis. Bulletin of Dermatology and Venereology. Russian Journal. 2017;93(5):52-63. (in Russian)

[12] Самцов А.В., Хайрутдинов В.Р., Бакулев А.Л., Кубанов А.А., Каримова А.Э., Артемьева А.В., Коротаева Т.В. Эффективность и безопасность препарата BCD-085 – оригинального моноклонального антитела против интерлейкина-17 у пациентов со среднетяжелым и тяжелым вульгарным псориазом. Результаты II фазы международного многоцентрового сравнительного рандомизированного двойного слепого плацебо-контролируемого клинического исследования // Вестник дерматологии и венерологии. 2017;93(5):52-63.

[13] Olisova OYu, Teplyuk NP, Pinegin VB. Modern methodes of psoriasis treatment. Russian Journal of Medicine. 2015;23(9):483-4. (in Russian)

[14] Олисова О.Ю., Теплюк Н.П., Пинегин В.Б. Современные методы лечения псориаза // Русский медицинский журнал. 2015;23(9):483-4.

[15] Kokhan MM, Keniksfest YuV, Grishaeva EV, Shefer AYu, Rimar OG. Mechanisms of psoriatic plaques formation and combined balneophoto-chemotherapy of psoriasis vulgaris patients. Lechasсhi Vrach. Russian Journal. 2013;(10):16-9. (in Russian)

[16] Кохан М.М., Кениксфест Ю.В., Гришаева Е.В., Шефер А.Ю., Римар О.Г. Механизм формирования псориатической бляшки и комбинированная бальнеофотохимиотерапия больных вульгарным псориазом // Лечащий врач. 2013;(10):16-9.

[17] Anupam M, Fallen RS, Cavalcante LH. Cytokine-based therapy in psoriasis. Clin Rev Allergy Immunol. 2013;44(2):173-82.

[18] Anupam M., Fallen R.S., Cavalcante L.H. Cytokine-based therapy in psoriasis. Clin Rev Allergy Immunol. 2013;44(2):173-82.

[19] Antoniu SA. Targeting the TNF-alpha pathway in sarcoidosis. Expert Opin Ther Targets. 2010;14(1):21-9.

[20] Antoniu S.A. Targeting the TNF-alpha pathway in sarcoidosis. Expert Opin Ther Targets. 2010;14(1):21-9.

[21] Baker BS, Laman JD, Powles A. Peptidoglycan and peptidoglycan-specific Th1 cells in psoriatic skin lesions. J Pathol. 2006;209(2):174-81.

[22] Baker B.S., Laman J.D., Powles A. Peptidoglycan and peptidoglycan-specific Th1 cells in psoriatic skin lesions. J Pathol. 2006;209(2):174-81.

[23] Gudjonsson JE, Ding J, Johnston А. Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models. J Invest Dermatol. 2010;130(7):1829-40.

[24] Gudjonsson J.E., Ding J., Johnston А. Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models. J Invest Dermatol. 2010;130(7):1829-40.

[25] Warren RB, Smith CH, Yiu Zenas ZN, Ashcroft DM, Barker JN, Burden AD, et al. Differential drug survival of biologic therapies for the treatment of psoriasis: a prospective observational cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). J Invest Dermatol. 2015;135(11):2632-40.

[26] Warren R.B., Smith C.H., Yiu Zenas Z.N., Ashcroft D.M., Barker J.N., Burden A.D., et al. Differential drug survival of biologic therapies for the treatment of psoriasis: a prospective observational cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). J Invest Dermatol. 2015;135(11):2632-40.

[27] Kulikov AG, Shakhova AS. The role of physical factors in the combined treatment of psoriasis (a scientific review). Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2013;(1):44-51. (in Russian)

[28] Куликов А.Г., Шахова А.С. Роль физических факторов в комплексной терапии псориаза // Физиотерапия, бальнеология и реабилитация. 2013;12(1):44-51.

[29] Badalov NG, Konchugova TV, Marchenkova LA, Persiyanova-Dubrova AL, Martynova EYu. Role of nondrug methods in a package of measures for the prevention and treatment of osteoporosis: A review of literature. Modern Rheumatology. Russian Journal. 2016;10(3):62-8. (in Russian)

[30] Бадалов Н.Г., Кончугова Т.В., Марченкова Л.А., Персиянова-Дуброва А.Л., Мартынова Е.Ю. Роль немедикаментозных методов в комплексе мероприятий по профилактике и лечению остеопороза (обзор литературы) // Современная ревматология. 2016;10(3):62-8.

[31] Shani J, Harari M, Hristakieva E, Seidl V, Bar-Giyora J. Dead-Sea climatotherapy versus other modalities of treatment for psoriasis: comparative cost-effectiveness. Int J Dermatol. 1999;38(4):252-62.

[32] Shani J., Harari M., Hristakieva E., Seidl V., Bar-Giyora J. Dead-Sea climatotherapy versus other modalities of treatment for psoriasis: comparative cost-effectiveness. Int J Dermatol. 1999;38(4):252-62.

[33] Popov YuV, Gulov OA, Vasenko VI. On the structure and composition of the silt strata of Lake Saki (Crimea). Journal of Domestic Geology. Russian Journal. 2015;(3):45-52. (in Russian)

[34] Попов Ю.В., Гулов О.А., Васенко В.И. О строении и составе толщи илов Сакского озера (Крым) // Отечественная геология. 2015;(3):45-52.

[35] Harari M, Sela Y, Ingber A, Vardy D. Dead-Sea climatotherapy for psoriasis vulgaris: analysis of short-term results. Glob Dermatol. 2016;3(3):295-301. DOI: 10.15761/GOD.1000177

[36] Harari M., Sela Y., Ingber A., Vardy D. Dead-Sea climatotherapy for psoriasis vulgaris: analysis of short-term results. Glob Dermatol. 2016;3(3):295-301. DOI: 10.15761/GOD.1000177

[37] Kotova IK, Kayukova EP, Mordukhai-Boltovskaya LV, Hlatonova NV, Kotov SR. Pattern of the composition formation of oozy mud from the Dead Sea and salt lakes of Crimea. Vestnik of St.Peresburg State University. Series 7. Geology. Geography. 2015;(2):85-102. (in Russian)

[38] Котова И.К., Каюкова Е.П., Мордухай-Болтовская Л.В., Платонова Н.В., Котов С.Р. Закономерности формирования состава иловых грязей Мертвого моря и соляных озер Крыма // Вестник Санкт-Петербургского государственного университета. Серия 7. Геология. География. 2015;(2):85-102.

[39] Mi Young Kim, Eun Jin Kim, Young-Nam Kim, Changsun Choi, Bog-Hieu Lee. Effects of a-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats. Nutr Res Pract. 2011;5(5):421-8.

[40] Kolpakova AF, Sharipov RN, Kolpakov FA. Transcription factor NF-kB plays a key role in the regulation of genes involved in inflammatory and immune responses. Siberian Medical Review. Russian Journal. 2009;(3):7-12. (in Russian)

[41] Колпакова А.Ф., Шарипов Р.Н., Колпаков Ф.А. Транскрипционный фактор NF-kB играет ключевую роль в регуляции генов, участвующих в воспалительных и иммунных реакциях // Сибирское медицинское обозрение. 2009;(3):7-12.

[42] Fedotchenko AA. Mud Treatment (Peloidotherapy). Siberian Medical Journal. Russian Journal. 2010;(6):273-75. (in Russian)

[43] Федотченко А.А. Грязелечение (Пелоидотерапия) // Сибирский медицинский журнал. 2010;(6):273-5.

[44] Imanaeva AYa, Zalyalyutdinova LN. Pathogenetic raionale for antioxidant administration in treatment of rheumatoid arthritis. Modern Problems of Science and Education. Russian Journal. 2013;(2):100. (in Russian)

[45] Иманаева А.Я., Залялютдинова Л.Н. Патогенетическое обоснование применения антиоксидантов в лечении рематоидного артрита // Современные проблемы науки и образования. 2013;(2):100.

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