Transdermal redermalization in rosacea: Rehab procedures in intercurrent period

Abstract

Background: The authors presented their own experiences of skin restoration in patients with rosacea after a course of active therapy using transdermal redermalization.

Aim: The course of cosmetic correction procedures using this method aimed to restore the energy potential of cells, water balance, and structures of the dermal elastin fibers, normalize microcirculation processes, and create an optimal physiological environment for the mitotic activity of epidermal cells.

Materials and methods: An innovative method of transdermal redermalization represents the administration of a drug containing hyaluronic acid and sodium succinate using the technique of papular intradermal injections, taking into account the peculiarities of lymphatic drainage in the facial area.

Results: To assess the therapy’s efficiency, noninvasive monitoring of changes in morphological structures of the skin was performed using confocal laser scanning microscopy.

Conclusions: The authors revealed the high efficiency of the method, which controls the remission state for a long term, subsequently avoiding drug therapy

Keywords

rosacea / transdermal redermalization / Hyalual / succinic acid / sodium succinate / hyaluronic acid / confocal laser scanning microscopy

References

[1] Tan J, Steinhoff M, Berg M, Del Rosso J, Layton A, Leyden J, et al.; Rosacea International Study Group. Shortcomings in rosacea diagnosis and classification. Br J Dermatol. 2017;176(1):197-9.

[2] Tan J., Steinhoff M., Berg M., Del Rosso J., Layton A., Leyden J., et al. Rosacea International Study Group. Shortcomings in rosacea diagnosis and classification. Br J Dermatol. 2017;176(1):197-9.

[3] Picardo M, Ottaviani M. Skin microbiome and skin disease: the example of rosacea. J Clin Gastroenterol. 2014;48(Suppl.1):85-6.

[4] Picardo M., Ottaviani M. Skin microbiome and skin disease: the example of rosacea. J Clin Gastroenterol. 2014;48(Suppl.1):85-6.

[5] Rusina TS, Snarskaya ES. Erythematotelangiectatic rosacea: the optimization of diagnostics and therapy. Russian Journal of Skin and Venereal Diseases. 2019;22 (3-4):111-20. (in Russian)

[6] Русина Т.С., Снарская Е.С Эритематозно-телеангиоэктатический подтип розацеа: оптимизация диагностики и разработка комплексной терапии // Российский журнал кожных и венерических болезней. 2019;22(3-4):111-20.

[7] Araviyskaya ER, Samtsov AV. Federal clinical guidelines of therapy of patients with rosacea. Moscow: Russian Society of Dermatologists and Cosmetologists; 2015. (in Russian)

[8] Аравийская Е.Р., Самцов А.В. Федеральные клинические рекомендации по ведению больных розацеа. М.: Российское общество дерматологов и косметологов; 2015.

[9] Khayrutdinov VR. Rosacea: modern concepts of the pathogenesis, clinical picture and treatment. Effective pharmacology. 2014;(19):32-7 (in Russian)

[10] Хайрутдинов В.Р. Розацеа: современные представления о патогенезе, клинической картине и лечении // Эффективная фармакотерапия. 2014;19:32-7.

[11] Steinhoff M, Schmelz M, Schauber J. Facial erythema of rosacea – aetiology, different pathophysiologies and treatment options. Acta Derm Venereol. 2016;96(5):579-86.

[12] Steinhoff M., Schmelz M., Schauber J. Facial erythema of rosacea – aetiology, different pathophysiologies and treatment options. Acta Derm Venereol. 2016;96(5):579-86.

[13] Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol. 2013;69(6, Suppl. 1):S15-26.

[14] Steinhoff M., Schauber J., Leyden J.J. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol. 2013;69(6,Suppl.1):S15-26.

[15] Ariza AC, Deen PM, Robben JH. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Front Endocrinol (Lausanne). 2012;3:22.

[16] Ariza A.C., Deen P.M., Robben J.H. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Front Endocrinol (Lausanne). 2012;3:22.

[17] Lukyanova LD, Kirova Yu I, Germanova EL. Specific features of immediate expression of succinate-dependent receptor GPR91 in tissues during hypoxia. Bull Exp Biol Med. 2016;160(6):742-7.

[18] Lukyanova L.D., Kirova Yu.I., Germanova E.L. Specific features of immediate expression of succinate-dependent receptor GPR91 in tissues during hypoxia. Bull Exp Biol Med. 2016;160(6):742-7.

[19] Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N., et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008;9(11):1261-9.

[20] Rubic T., Lametschwandtner G., Jost S., Hinteregger S., Kund J., Carballido-Perrig N., et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008;9(11):1261-9.

[21] Liskina IV, Derkach NN, Kuzovkova SD. Comparative clinical and morphological study of the effect of two hyaluronic acid based products on the skin. Ukrainian Journal of Dermatology, Venereology, Cosmetology. 2010;(2):64-70. (in Russian)

[22] Лискина И.В., Деркач Н.Н., Кузовкова С.Д. Сравнительное клинико-морфологическое исследование влияния на кожу двух препаратов на основе гиалуроновой кислоты // Украинский журнал дерматологии, венерологии, косметологии. 2010;(2):64-70.

[23] Ulusal B. Platelet-rich plasma and hyaluronic acid - an efficient biostimulation method for face rejuvenation. J Cosmet Dermatol. 2017;16(1):112-9.

[24] Grant-Kels JM, Pellacani G, Longo C. Reflectance confocal microscopy clinical applications: the skin from inside. Dermatol Clin. 2016;34(4):xiii–xiv.

[25] Grant-Kels J.M., Pellacani G., Longo C. Reflectance confocal microscopy clinical applications: the skin from inside. Dermatol Clin. 2016;34(4):xiii–xiv.

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